caa a22 4500 397496656 CHVBK 20180308164522.0 cr unu---uuuuu 161202e199503 xx s 000 0 eng 10.1016/S1010-7940(05)80062-4 doi (NATIONALLICENCE)oxford-10.1016/S1010-7940(05)80062-4 Comparison of propafenone to atenolol for the prophylaxis of postcardiotomy supraventricular tachyarrhythmias: a prospective trial [Elektronische Daten] To compare the efficacy of propafenone to atenolol in the prevention ofsupraventricular tachyarrhythmias (SVT) following cardiac surgery, 207consecutive patients were randomly allocated to receive either propafenone300 mg twice daily (105 patients) or atenolol 50 mg once daily (102patients) orally for 7 days after operation. Double blinding was achievedusing placebos. The end point was the development of a SVT which wassymptomatic, recurrent, or lasting over 2 minutes, or the occurrence ofadverse effects possibly attributable to the drugs. The groups were wellmatched for age, sex, bypass- and cross-clamp times, and other data.Thirteen patients in the propafenone group and 11 in the atenolol groupdeveloped SVT during the first week after operation. (P = 0.89, nonsignificant, chi-squared with Yates' correction). In our study propafenoneand atenolol were of approximately equal efficacy in preventing postcardiotomy SVT. Propafenone may have an advantage in being less negativelyinotropic than atenolol; it could therefore be used in patients with poorleft ventricular function or marginal haemodynamics when a beta blocker iscontraindicated. © Springer-Verlag 1995 European Journal of Cardio-Thoracic Surgery Elsevier Science B.V. 9/3(1995-03), 146-149 1010-7940 9:3<146 1995 9 ejcts https://doi.org/10.1016/S1010-7940(05)80062-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1016/S1010-7940(05)80062-4 text/html Onlinezugriff via DOI NATIONALLICENCE 773 0- European Journal of Cardio-Thoracic Surgery Elsevier Science B.V 9/3(1995-03), 146-149 1010-7940 9:3<146 1995 9 ejcts Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford