caa a22 4500 397496664 CHVBK 20180308164522.0 cr unu---uuuuu 161202e199503 xx s 000 0 eng 10.1016/S1010-7940(05)80060-0 doi (NATIONALLICENCE)oxford-10.1016/S1010-7940(05)80060-0 Delivery pressure of the cardioplegic solution influences myocardial protection [Elektronische Daten] To investigate whether cardioplegic solution (CS) delivery pressureinfluences myocardial protection, intermittent infusions of CS at differentpressures were used in an isolated Langendorff rat heart preparation. Ingroup 1 the hearts were kept arrested for 210 min at 12 degrees C withintermittent infusions of 5 ml CS every 20 min at 30 cm H2O (22 mmHg)pressure, in group 2 the same volume of CS was infused at 100 cm H2O (73.5mmHg) pressure, in group 3 at 145 cm H2O (106.5 mmHg) pressure and in group4 at 238 cm H2O (175 mmHg) pressure. There was a significantly highercoronary resistance in groups 1 and 4 (7.3 +/- 0.2 RU and 6.9 +/- 0.2 RU)than in groups 2 and 3 (4.2 +/- 0.2 RU and 4.2 +/- 0.2 RU) (P ≪ 0.05)during the ischemic period. There were no significant differences betweengroup 2 and 3 in the reperfusion period. Groups 2 and 3 showed highercoronary flow and left ventricle developed pressure than group 1 and 4.Hearts from group 1 and 4 had lower adenosine triphosphate (7.88 +/- 0.44mumol.g-1, 5.56 +/- 0.56 mumol.g-1) (P ≪ 0.05) and creatine phosphate(24.66 +/- 0.47 mumol.g-1, 15.34 +/- 0.94 mumol.g-1) (P ≪ 0.05) contentat the end of the reperfusion period than group 2 (10.56 +/- 0.41mumol.g-1, 30.06 +/- 0.38 mumol.g-1) and group 3 (14.13 +/- 0.69 mumol.g-1,35.25 +/- 0.78 mumol.g-1).(ABSTRACT TRUNCATED AT 250 WORDS) © Springer-Verlag 1995 European Journal of Cardio-Thoracic Surgery Elsevier Science B.V. 9/3(1995-03), 139-142 1010-7940 9:3<139 1995 9 ejcts https://doi.org/10.1016/S1010-7940(05)80060-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1016/S1010-7940(05)80060-0 text/html Onlinezugriff via DOI NATIONALLICENCE 773 0- European Journal of Cardio-Thoracic Surgery Elsevier Science B.V 9/3(1995-03), 139-142 1010-7940 9:3<139 1995 9 ejcts Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford