caa a22 4500 397496680 CHVBK 20180308164522.0 cr unu---uuuuu 161202e199503 xx s 000 0 eng 10.1016/S1010-7940(05)80061-2 doi (NATIONALLICENCE)oxford-10.1016/S1010-7940(05)80061-2 Suppressed fibrinolysis after administration of low-dose aprotinin: reduced level of plasmin-alpha2-plasmin inhibitor complexes and postoperative blood loss [Elektronische Daten] Various clinical investigation have shown that aprotinin therapy reducesbleeding after open-heart operations. In this study low-dose aprotinin,30,000 KIU/kg in the cardiopulmonary bypass (CPB) priming volume and 7,500KIU/kg intravenously each hour during CPB, was used in ten patientsundergoing primary myocardial revascularization or surgery for valvulardiseases. Another ten patients served as controls. Blood loss, plateletcount and plasma levels of hemoglobin, antithrombin III, fibrinogen,fibrinogen degradation products (FDP), total plasmin inhibitor andalpha2-plasmin inhibitor-plasmin complexes were evaluated at ninepreoperative, intraoperative and postoperative points. Intraoperative andpostoperative blood loss was significantly reduced in the aprotinin group.There was no significant difference between the two groups in plateletcount and levels of hemoglobin and antithrombin III. A significant increasein FDP during CPB in the control group indicated hyperfibrinolysis. Thelevels of plasmin inhibitor were significantly reduced during CPB in thecontrol group. The alpha 2- plasmin inhibitor-plasma complex levels,indicating the plasmin activity, were significantly reduced in theaprotinin group. These results confirmed that low-dose aprotinin reducedblood loss with the prevention of hyperfibrinolysis during CPB anddemonstrated improved hemostasis. © Springer-Verlag 1995 European Journal of Cardio-Thoracic Surgery Elsevier Science B.V. 9/3(1995-03), 143-145 1010-7940 9:3<143 1995 9 ejcts https://doi.org/10.1016/S1010-7940(05)80061-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1016/S1010-7940(05)80061-2 text/html Onlinezugriff via DOI NATIONALLICENCE 773 0- European Journal of Cardio-Thoracic Surgery Elsevier Science B.V 9/3(1995-03), 143-145 1010-7940 9:3<143 1995 9 ejcts Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford