caa a22 4500 397496796 CHVBK 20180308164523.0 cr unu---uuuuu 161202e199504 xx s 000 0 eng 10.1016/S1010-7940(05)80153-8 doi (NATIONALLICENCE)oxford-10.1016/S1010-7940(05)80153-8 Extracorporeal membrane oxygenation with heparin-coated systems in a 13- month-old infant with acute hypoxic respiratory failure after correction of tetralogy of Fallot [Elektronische Daten] Hemorrhagic disorders due to systemic heparinization are frequent duringextracorporeal lung support (veno-venous extracorporeal membraneoxygenation: vv-ECMO). The development of heparin-coated systems hasreduced the need for high-dose heparinization. Whereas the use of theseheparin-coated membrane lungs and tubings has been described in formerstudies in adults, only few reports exist in children. This case reportdescribes the application of a heparin-coated extracorporeal system forlong-term vv-ECMO in a 13-month-old infant suffering from acute hypoxicrespiratory failure after correction of tetralogy of Fallot. Onlymoderately elevated levels of activated clotting time (ACT, 120-160 s) andactivated partial thromboplastin time (aPTT, 40-60 s) were necessary toavoid thrombotic events in the extracorporeal system. Thoracotomies wereperformed twice without bleeding complications by discontinuation of thesystemic heparinization. We conclude that the use of heparin-coatedmembrane lungs in infants may improve the safety of extracorporeal lungsupport and permits surgical intervention without major risk ofbleeding. © Springer-Verlag 1995 European Journal of Cardio-Thoracic Surgery Elsevier Science B.V. 9/4(1995-04), 226-229 1010-7940 9:4<226 1995 9 ejcts https://doi.org/10.1016/S1010-7940(05)80153-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1016/S1010-7940(05)80153-8 text/html Onlinezugriff via DOI NATIONALLICENCE 773 0- European Journal of Cardio-Thoracic Surgery Elsevier Science B.V 9/4(1995-04), 226-229 1010-7940 9:4<226 1995 9 ejcts Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford