caa a22 4500 397496974 CHVBK 20180308164523.0 cr unu---uuuuu 161202e199509 xx s 000 0 eng 10.1016/S1010-7940(95)80049-2 doi (NATIONALLICENCE)oxford-10.1016/S1010-7940(95)80049-2 Maldistribution of the cerebral blood flow in retrograde cerebral perfusion [Elektronische Daten] Retrograde cerebral perfusion (RCP) through a superior vena caval (SVC)cannula has now become a useful alternative for brain protection duringaortic arch operations. However, little is still known about itsphysiological effects, especially regarding the flow distribution in thebrain. We studied the cerebral blood flow distribution under hypothermicconditions using mongrel dogs (n = 6, weighing 9.5 to 14 kg). We measuredthe cerebral tissue blood flow of the cortex with a laser Doppler flowmeterand cerebral tissue blood flow of the medulla using the hydrogen clearancemethod. The cerebral blood distribution at 28 degrees C with a whole bodybypass flow of 100 ml/kg per min and aortic pressure of 88.3 +/- 20.4 mmHgwas used as a control. Then the body temperature was decreased to 20degrees C and the descending aorta was cross-clamped just distal to theorigin of the left subclavian artery to establish antegrade cerebralperfusion (ACP). The perfusion flow was decreased to 54.8 +/- 12.4 ml/kgper min so as to make the aortic pressure similar to the controlconditions. After measuring the cerebral blood flow distribution in ACP,the perfusion was then switched to RCP through the bilateral internalmaxillary vein and the SVC pressure was kept at 40 mmHg. In RCP, thecerebral blood flow of the medulla was quite similar to that in ACP (12.4ml/min per 100 g versus 15.2 ml/min per 100 g, NS). In contrast, thecerebral blood flow of the cortex significantly decreased to 16% of theflow in ACP (7.8 perfusion units versus 50 perfusion units, P < 0.01).Because of the maldistribution of the cerebral blood flow in RCP, carefulattention should be paid to the clinical application of this method. European Journal of Cardio-Thoracic Surgery Elsevier Science B.V. 9/9(1995-09), 496-500 1010-7940 9:9<496 1995 9 ejcts https://doi.org/10.1016/S1010-7940(95)80049-2 text/html Onlinezugriff via DOI 1 abstract jats NATIONALLICENCE 856 40 https://doi.org/10.1016/S1010-7940(95)80049-2 text/html Onlinezugriff via DOI NATIONALLICENCE 773 0- European Journal of Cardio-Thoracic Surgery Elsevier Science B.V 9/9(1995-09), 496-500 1010-7940 9:9<496 1995 9 ejcts Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford