caa a22 4500 397501803 CHVBK 20180308164534.0 cr unu---uuuuu 161202e19950801xx s 000 0 eng 10.1093/oxfordjournals.rpd.a082788 doi 0144-8420 pii (NATIONALLICENCE)oxford-10.1093/oxfordjournals.rpd.a082788 A New Method to Study Low Dose Radiation Damage [Elektronische Daten] [H.W. Reist, W. Burkard, D. Calabrese, P. Doria, E. Heimgartner, D. Knespl, M. Kohler, B. Larsson, R. Leemann, Ch. Markovits, Ch. Michel, J. Stepanek, S. Teichmann, S. Tuor] To investigate low dose effects such as single traversals of charged particles through individual cells, the number of cells that has to be exposed is very high. The presented palladium island technique combines the possibility of irradiating more than a thousand cells simultaneously with an efficient colony-forming ability in soft agar and the capability to measure the track position. In addition to a vertical beam line which allows the cells to be exposed horizontally to protons or a particles, and irradiation chamber and a cell chamber were constructed which provide the cells with an environment of 5-10% CO2 and 90-95% air at 310 K. The cell chamber is designed to make it possible to localise a particle passage through the cell nucleus by measuring the track position in the attached detector and to avoid ambiguities in the analysis of the biological effects as the cells proliferate and form colonies. Using statistical calculations the experimental results are interpreted in terms of relations between the frequency of each biological endpoint and the track structure parameters. Radiation Protection Dosimetry Reist H.W. aut Burkard W. aut Calabrese D. aut Doria P. aut Heimgartner E. aut Knespl D. aut Kohler M. aut Larsson B. aut Leemann R. aut Markovits Ch aut Michel Ch aut Stepanek J. aut Teichmann S. aut Tuor S. aut Radiation Protection Dosimetry Oxford University Press 61/1-3(1995-08-01), 221-224 0144-8420 61:1-3<221 1995 61 rpd https://doi.org/10.1093/oxfordjournals.rpd.a082788 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.rpd.a082788 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Reist H.W. aut NATIONALLICENCE 700 1- Burkard W. aut NATIONALLICENCE 700 1- Calabrese D. aut NATIONALLICENCE 700 1- Doria P. aut NATIONALLICENCE 700 1- Heimgartner E. aut NATIONALLICENCE 700 1- Knespl D. aut NATIONALLICENCE 700 1- Kohler M. aut NATIONALLICENCE 700 1- Larsson B. aut NATIONALLICENCE 700 1- Leemann R. aut NATIONALLICENCE 700 1- Markovits Ch aut NATIONALLICENCE 700 1- Michel Ch aut NATIONALLICENCE 700 1- Stepanek J. aut NATIONALLICENCE 700 1- Teichmann S. aut NATIONALLICENCE 700 1- Tuor S. aut NATIONALLICENCE 773 0- Radiation Protection Dosimetry Oxford University Press 61/1-3(1995-08-01), 221-224 0144-8420 61:1-3<221 1995 61 rpd Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford