caa a22 4500 397502435 CHVBK 20180308164535.0 cr unu---uuuuu 161202e19951001xx s 000 0 eng 10.1093/oxfordjournals.rpd.a082812 doi 0144-8420 pii (NATIONALLICENCE)oxford-10.1093/oxfordjournals.rpd.a082812 The Evolutionary Reserve Cell Concept and Model of Cellular Response Induced by Low Doses of Radiation [Elektronische Daten] [D.M. Spitkovsky, T.A. Talyzina] The model is based on the concept of programmed initiation of genetic damage in sub-populations of specific evolutionary reserve cells (ERC). The model quantitatively predicts a dose response of genetic lesions at low dose range and furnishes an explanation of the minimum observed in the dose-response curve at doses corresponding to one (on the average) event of energy deposition per ERC. The complex shape of the dose-response curve is demonstrated to result from superposition of processes in different sub-populations within the exposed cell population (at low doses mainly in ERC). Programmed initiation of genetic lesions in ERC requires two hits to cell membrane and probably, at the same time, to the cell nucleus. The equation for dicentric yield in human lymphocytes as a function of dose describes the experimental observations rather well. Radiation Protection Dosimetry Spitkovsky D.M. aut Talyzina T.A. aut Radiation Protection Dosimetry Oxford University Press 62/1-2(1995-10-01), 23-26 0144-8420 62:1-2<23 1995 62 rpd https://doi.org/10.1093/oxfordjournals.rpd.a082812 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.rpd.a082812 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Spitkovsky D.M. aut NATIONALLICENCE 700 1- Talyzina T.A. aut NATIONALLICENCE 773 0- Radiation Protection Dosimetry Oxford University Press 62/1-2(1995-10-01), 23-26 0144-8420 62:1-2<23 1995 62 rpd Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford