caa a22 4500 397502842 CHVBK 20180308164536.0 cr unu---uuuuu 161202e19950101xx s 000 0 eng 10.1093/oxfordjournals.rpd.a082571 doi 0144-8420 pii (NATIONALLICENCE)oxford-10.1093/oxfordjournals.rpd.a082571 Physiologically Based Pharmacokinetics Model for Estimating Urinary Excretion of Short Half-Life Nuclides in Nuclear Medicine [Elektronische Daten] [K. Akahane, M. Kai, E. Konishi, T. Kusama, Y. Aoki] The biokinetic model in ICRP 53 is used for calculating absorbed dose to each organ of a patient in nuclear medicine. The ICRP model is a simple compartment model based on human data; however, the model cannot produce the biokinetics of radiopharmaceuticals under various physiological conditions. On the other hand, a physiologically based pharmacokinetics model (PBPK model) can describe the flow of radiopharmaceuticals as a compartment model for any physiological conditions theoretically. The PBPK model was applied especially for the kidney-bladder dynamics, and similar results obtained compared with the ICRP model. This suggests the possibility of the PBPK model for predicting the biokinetics of radiopharmaceuticals under various physiological conditions. Radiation Protection Dosimetry Akahane K. aut Kai M. aut Konishi E. aut Kusama T. aut Aoki Y. aut Radiation Protection Dosimetry Oxford University Press 57/1-4(1995-01-01), 409-412 0144-8420 57:1-4<409 1995 57 rpd https://doi.org/10.1093/oxfordjournals.rpd.a082571 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.rpd.a082571 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Akahane K. aut NATIONALLICENCE 700 1- Kai M. aut NATIONALLICENCE 700 1- Konishi E. aut NATIONALLICENCE 700 1- Kusama T. aut NATIONALLICENCE 700 1- Aoki Y. aut NATIONALLICENCE 773 0- Radiation Protection Dosimetry Oxford University Press 57/1-4(1995-01-01), 409-412 0144-8420 57:1-4<409 1995 57 rpd Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford