caa a22 4500 397503709 CHVBK 20180308164538.0 cr unu---uuuuu 161202e19951101xx s 000 0 eng 10.1093/oxfordjournals.rpd.a082838 doi 0144-8420 pii (NATIONALLICENCE)oxford-10.1093/oxfordjournals.rpd.a082838 Survival of Alpha Particle Irradiated Cells as a Function of the Shape and Size of the Sensitive Volume (Nucleus) [Elektronische Daten] [T.G. Stinchcomb, J.C. Roeske] Microdosimetry is the study of the stochastic variation of energy deposited within sub-cellular targets. As such, the size and shape of the critical target (i.e. cell nucleus) are essential when considering microdosimetric quantities. In this work, a microdosimetric analysis examines the expected cell survival as a function of the size and shape of the cell nucleus under conditions of irradiation by radionuclides emitting alpha particles. The results indicate that, in general, cell survival is relatively insensitive to changes in the shape of the cell nucleus when the volume is held constant. However, cell survival is a strong function of the variation in the size of the target. These results are useful when analysing the results of cell survival experiments for alpha particle emitters. Radiation Protection Dosimetry Stinchcomb T.G. aut Roeske J.C. aut Radiation Protection Dosimetry Oxford University Press 62/3(1995-11-01), 157-164 0144-8420 62:3<157 1995 62 rpd https://doi.org/10.1093/oxfordjournals.rpd.a082838 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.rpd.a082838 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stinchcomb T.G. aut NATIONALLICENCE 700 1- Roeske J.C. aut NATIONALLICENCE 773 0- Radiation Protection Dosimetry Oxford University Press 62/3(1995-11-01), 157-164 0144-8420 62:3<157 1995 62 rpd Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford