caa a22 4500 397503989 CHVBK 20180308164539.0 cr unu---uuuuu 161202e19950701xx s 000 0 eng 10.1093/oxfordjournals.rpd.a082735 doi 0144-8420 pii (NATIONALLICENCE)oxford-10.1093/oxfordjournals.rpd.a082735 Johnson (INVITED) N.F. INVITED Radiobiology of Lung Target Cells [Elektronische Daten] [N.F. Johnson (INVITED)] Little is known about the cells at risk in the nasopharyngeal region and peripheral lung, risk estimates in the tracheobronchial airways are based on the basal cell as the cell at risk and the nucleus as the target for radiation damage. However, these assumptions are being challenged; research shows that instead of the basal cell, the secretory cell may be the cell at risk and that irradiating the extranuclear regions of the cell can also result in genotoxicity. Human populations exposed to high doses of densely and sparsely ionising radiation have an increased risk of lung cancer; however, the distribution of the various tumour types in exposed individuals is similar to that found in the non-exposed, which indicates that there is not a population of cells in the lung that is overtly sensitive to radiation. To provide a more biologically validated estimate of risk from radiation, a better understanding is needed of the cellular and molecular changes induced by radiation exposure and how these changes relate to pulmonary cancer. Radiation Protection Dosimetry Radiation Protection Dosimetry Oxford University Press 60/4(1995-07-01), 327-330 0144-8420 60:4<327 1995 60 rpd https://doi.org/10.1093/oxfordjournals.rpd.a082735 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.rpd.a082735 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Johnson (INVITED) N.F. INVITED NATIONALLICENCE 773 0- Radiation Protection Dosimetry Oxford University Press 60/4(1995-07-01), 327-330 0144-8420 60:4<327 1995 60 rpd Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford