caa a22 4500 397504810 CHVBK 20180308164541.0 cr unu---uuuuu 161202e19950201xx s 000 0 eng 10.1093/oxfordjournals.rpd.a082603 doi 0144-8420 pii (NATIONALLICENCE)oxford-10.1093/oxfordjournals.rpd.a082603 Theory of Mutation Induction by Accelerated Very Heavy Ions in Cells [Elektronische Daten] [S. Kozubek, G. Horneck, L. Rýznar] Stochastic effects of ionising radiation in humans are related to mutation induction in cells. Therefore experimental data on mutation induction represents one of the endpoints used for the estimation of risk in radiation protection. Only very rough estimates can be made owing to the fact that a suitable theoretical approach does not exist. A simple method is proposed for the evaluation of the efficiency of mutation induction by accelerated very heavy ions in mammalian cells. The approach is based on the calculation of the fraction of energy deposited by accelerated particles in indirect collision (hits) in the cells. Two different modes of particle mutagenic action can be distinguished. s ray mutagenesis is related to those particles that preferentially kill the cells in direct hits. Track-core mutagenesis arises from direct hits and is observed for lighter ions or ions with very high energy (LET (500 keV.µm-1). Available experimental data agree reasonably well with the results based on theory. Radiation Protection Dosimetry Kozubek S. aut Horneck G. aut Rýznar L. aut Radiation Protection Dosimetry Oxford University Press 58/2(1995-02-01), 93-101 0144-8420 58:2<93 1995 58 rpd https://doi.org/10.1093/oxfordjournals.rpd.a082603 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.rpd.a082603 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kozubek S. aut NATIONALLICENCE 700 1- Horneck G. aut NATIONALLICENCE 700 1- Rýznar L. aut NATIONALLICENCE 773 0- Radiation Protection Dosimetry Oxford University Press 58/2(1995-02-01), 93-101 0144-8420 58:2<93 1995 58 rpd Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford