caa a22 4500 397504861 CHVBK 20180308164542.0 cr unu---uuuuu 161202e19950701xx s 000 0 eng 10.1093/oxfordjournals.rpd.a082731 doi 0144-8420 pii (NATIONALLICENCE)oxford-10.1093/oxfordjournals.rpd.a082731 McClellan (INVITED) R.O. INVITED Hanford Animal Studies of Radioiodine [Elektronische Daten] [R.O. McClellan (INVITED)] Very early in the Hanford nuclear project, 131I was recognised as a key radionuclide whose release from the nuclear fuel cycle would need to be closely controlled and monitored. Later, concern emerged for 131I as significant fallout radionuclide from nuclear weapons testing. To provide a scientific basis for controlling exposures, a major multifaceted research programme was conducted at Hanford. A major portion of the research programme focused on evaluating the radiotoxicity of 131I to domestic sheep because of their likelihood of receiving radioiodine exposure via ingestion of contaminated forage. The sheep studies involved multiple exposure levels and multigenerational studies conducted over a period of years and defined the effects of 131I from exposures producing acute effects down to minimal-effect levels and no-observed-effect levels. Other studies examined the influence of route of exposure (oral, inhalation, intravenous, subcutaneous, and dermal) on the disposition of 131I. In all cases, the patterns of uptake and distribution were quite similar, with rapid accumulation of 131I in the thyroid. Another study in which dairy cattle ingested 131I established the relationship among levels in the cow's diet, cow's thyroid, milk, and the thyroid of humans drinking the milk. Although the research was conducted over 30 years ago, it was innovative in its experimental design judged by today's standards and yielded results that will continue to be of substantial value in assessing the risks to animals and humans of 131I exposure as long as such concerns exist. Radiation Protection Dosimetry Radiation Protection Dosimetry Oxford University Press 60/4(1995-07-01), 295-305 0144-8420 60:4<295 1995 60 rpd https://doi.org/10.1093/oxfordjournals.rpd.a082731 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.rpd.a082731 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- McClellan (INVITED) R.O. INVITED NATIONALLICENCE 773 0- Radiation Protection Dosimetry Oxford University Press 60/4(1995-07-01), 295-305 0144-8420 60:4<295 1995 60 rpd Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford