caa a22 4500 397546580 CHVBK 20180308164739.0 cr unu---uuuuu 161202e19960301xx s 000 0 eng 10.1093/aesa/89.2.261 doi (NATIONALLICENCE)oxford-10.1093/aesa/89.2.261 Uric Acid in Anopheles Mosquitoes (Diptera: Culicidae): Effects of Collarless, Stripe, and White Mutations [Elektronische Daten] [Mark Q. Benedict, Allen Cohen, Anton J. Cornel, Donald L. Brummett] Anopheles mosquito larvae and pupae often have a layer of white pigment visible beneath the transparent cuticle on the dorsum of the abdomen and thorax. This pigment occurs in granules that are highly concentrated in ameboid-shaped cells of the parietal fat body. Mutations that affect the pattern or abundance, or both, of this pigment in A. albimanus Wiedemann and A. gambiae Giles are characterized by differences in the abundance of uric acid, whose levels range from 1.86 to 3.13 μg per larvae in individuals of 4 phenotypes having white pigmentation. Uric acid concentrations are higher in A. albimanus stripe+ individuals which also have the most prominent white pigment. Two other mutants, A. gambiae collarless and A. albimanus white eye, contain no detectable uric acid nor any white pigment. None of the mutants examined has reduced xanthine dehydrogenase activity nor altered XDH electrophoretic mobility. We suggest that the prominent white pigment is precipitated uric acid contained within specialized fat-body cells similar to urocytes. We discuss the genetic basis of mutants affecting uric acid deposition, and the pleiotropic effects of the eye-color mutations such as white. © 1996 Entomological Society of America Physiology, Biochemistry, and Toxicology nationallicence Anopheles nationallicence urate nationallicence purine transport nationallicence xanthine dehydrogenase nationallicence Benedict Mark Q. Centers for Disease Control and Prevention, Atlanta, GA 30341. aut Cohen Allen USDA-ARS Western Cotton Research Laboratory, Phoenix, AZ 85040. aut Cornel Anton J. Centers for Disease Control and Prevention, Atlanta, GA 30341. aut Brummett Donald L. USDA-ARS Western Cotton Research Laboratory, Phoenix, AZ 85040. aut Annals of the Entomological Society of America Oxford University Press 89/2(1996-03-01), 261-265 0013-8746 89:2<261 1996 89 aesa https://doi.org/10.1093/aesa/89.2.261 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/aesa/89.2.261 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Benedict Mark Q. Centers for Disease Control and Prevention, Atlanta, GA 30341 aut NATIONALLICENCE 700 1- Cohen Allen USDA-ARS Western Cotton Research Laboratory, Phoenix, AZ 85040 aut NATIONALLICENCE 700 1- Cornel Anton J. Centers for Disease Control and Prevention, Atlanta, GA 30341 aut NATIONALLICENCE 700 1- Brummett Donald L. USDA-ARS Western Cotton Research Laboratory, Phoenix, AZ 85040 aut NATIONALLICENCE 773 0- Annals of the Entomological Society of America Oxford University Press 89/2(1996-03-01), 261-265 0013-8746 89:2<261 1996 89 aesa Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford