caa a22 4500 397555156 CHVBK 20180308164759.0 cr unu---uuuuu 161202e199602 xx s 000 0 eng 10.1093/oxfordjournals.jbchem.a021228 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jbchem.a021228 Characterization of the Human Full-Length PTK7 cDNA Encoding a Receptor Protein Tyrosine Kinase-Like Molecule Closely Related to Chick KLG [Elektronische Daten] [Sang-Kyu Park, Hyoung-Song Lee, Seung-Taek Lee] A 220-bp fragment of PTK7 cDNA was previously cloned from normal human melanocyte RNAs by means of the reverse transcription-polymerase chain reaction [Lee, S.-T., Strunk, K.M., and Sprite, R.A. (1993) Oncogene 8, 3403-3410]. We now report the cloning of the human full-length PTK7 cDNA and its characterization. The 1,070-amino acid PTK7 polypeptide deduced from the cDNA sequence constitutes receptor protein tyrosine kinase (RPTK), but has several unusual residues in some of the highly conserved tyrosine kinase motifs. PTK7 mRNA was expressed at the highest level in a human erythroleukemia cell line among tested samples, and at relatively high levels in liver, lung, pancreas, kidney, placenta, and melanocytes. Human PTE7 is 72% identical to chick KLG, suggesting that PTK7 is homologous or possibly orthologous to chick KLG, and that these represent a new subfamily of RPTKs. © by the Journal of Biochemistry Rapid Communications nationallicence full-length cDNA nationallicence mRNA expression nationallicence PTK7 nationallicence RPTK-like molecule nationallicence transmem-brane receptor nationallicence Park Sang-Kyu Department of Biochemistry, College of Science, and Bioproducts Research Center, Yonsei University, Seoul 120-749, Republic of Korea aut Lee Hyoung-Song Department of Biochemistry, College of Science, and Bioproducts Research Center, Yonsei University, Seoul 120-749, Republic of Korea aut Lee Seung-Taek Department of Biochemistry, College of Science, and Bioproducts Research Center, Yonsei University, Seoul 120-749, Republic of Korea aut The Journal of Biochemistry Oxford University Press 119/2(1996-02), 235-239 0021-924X 119:2<235 1996 119 jbchem https://doi.org/10.1093/oxfordjournals.jbchem.a021228 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jbchem.a021228 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Park Sang-Kyu Department of Biochemistry, College of Science, and Bioproducts Research Center, Yonsei University, Seoul 120-749, Republic of Korea aut NATIONALLICENCE 700 1- Lee Hyoung-Song Department of Biochemistry, College of Science, and Bioproducts Research Center, Yonsei University, Seoul 120-749, Republic of Korea aut NATIONALLICENCE 700 1- Lee Seung-Taek Department of Biochemistry, College of Science, and Bioproducts Research Center, Yonsei University, Seoul 120-749, Republic of Korea aut NATIONALLICENCE 773 0- The Journal of Biochemistry Oxford University Press 119/2(1996-02), 235-239 0021-924X 119:2<235 1996 119 jbchem Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford