caa a22 4500 39755527X CHVBK 20180308164800.0 cr unu---uuuuu 161202e199602 xx s 000 0 eng 10.1093/oxfordjournals.jbchem.a021226 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jbchem.a021226 Structure Determination of an Immunopotentiator Peptide, Cinnamycin, Complexed with Lysophosphatidylethanolamine by 1H-NMR [Elektronische Daten] [Kazuo Hosoda, Masanao Ohya, Toshiyuki Kohno, Tadakazu Maeda, Shigeru Endo, Kaori Wakamatsu] The three-dimensional structure of a complex of cinnamycin, a 19-amino acid residue immunopotentiator peptide, and lysophosphatidylethanolamine was determined by 1H-NMR. The complex was cylindrical in shape, 11 Å in diameter and 26 Å in length, excluding the acyl chain of the phospholipid. The peptide had a hydrophobic pocket surrounded by . residues Phe-7 through Ala(S)-14 to bind to the head group of the ligand. Fitting of the head group to the hydrophobic pocket was so good that other than a glycerophosphoethanol-amine head group would be unable to fit the pocket. The goodness of the fitting is compatible with the strict specificity of ligand binding of the peptide. © by the Journal of Biochemistry Rapid Communications nationallicence cinnamycin nationallicence lysophosphatidylethanolamine nationallicence nuclear magnetic resonance nationallicence peptide-lipid interaction nationallicence three-dimensional structure nationallicence Hosoda Kazuo Department of Biochemical Sciences, Faculty of Engineering, Gunma University Tenjin-cho, Kiryu, Gunma 376 aut Ohya Masanao Department of Biochemical Sciences, Faculty of Engineering, Gunma University Tenjin-cho, Kiryu, Gunma 376 aut Kohno Toshiyuki Mitsubishi Kasei Institute of Life Sciences Minamiooya, Machida, Tokyo 194 aut Maeda Tadakazu Mitsubishi Kasei Institute of Life Sciences Minamiooya, Machida, Tokyo 194 aut Endo Shigeru Mitsubishi Kasei Institute of Life Sciences Minamiooya, Machida, Tokyo 194 aut Wakamatsu Kaori Department of Biochemical Sciences, Faculty of Engineering, Gunma University Tenjin-cho, Kiryu, Gunma 376 aut The Journal of Biochemistry Oxford University Press 119/2(1996-02), 226-230 0021-924X 119:2<226 1996 119 jbchem https://doi.org/10.1093/oxfordjournals.jbchem.a021226 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jbchem.a021226 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hosoda Kazuo Department of Biochemical Sciences, Faculty of Engineering, Gunma University Tenjin-cho, Kiryu, Gunma 376 aut NATIONALLICENCE 700 1- Ohya Masanao Department of Biochemical Sciences, Faculty of Engineering, Gunma University Tenjin-cho, Kiryu, Gunma 376 aut NATIONALLICENCE 700 1- Kohno Toshiyuki Mitsubishi Kasei Institute of Life Sciences Minamiooya, Machida, Tokyo 194 aut NATIONALLICENCE 700 1- Maeda Tadakazu Mitsubishi Kasei Institute of Life Sciences Minamiooya, Machida, Tokyo 194 aut NATIONALLICENCE 700 1- Endo Shigeru Mitsubishi Kasei Institute of Life Sciences Minamiooya, Machida, Tokyo 194 aut NATIONALLICENCE 700 1- Wakamatsu Kaori Department of Biochemical Sciences, Faculty of Engineering, Gunma University Tenjin-cho, Kiryu, Gunma 376 aut NATIONALLICENCE 773 0- The Journal of Biochemistry Oxford University Press 119/2(1996-02), 226-230 0021-924X 119:2<226 1996 119 jbchem Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford