caa a22 4500 397555415 CHVBK 20180308164800.0 cr unu---uuuuu 161202e199602 xx s 000 0 eng 10.1093/oxfordjournals.jbchem.a021223 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jbchem.a021223 Membrane-Type Matrix Metalloproteinases (MT-MMPs) in Tumor Metastasis [Elektronische Daten] [Hiroshi Sato, Motoharu Seiki] Activated gelatinase A is reportedly associated with tumor spread. We identified novel matrix metalloproteinases that localize on the cell surface and mediate the activation of progelatinase A. Thus, these progelatinase A activators were named membrane-type matrix metalloproteinase-1 and −2 (MT-MMP-1 and −2, respectively). MT-MMP-1 is overexpressed in malignant tumor tissues, including lung and stomach carcinomas that contain activated gelatinase A. This suggests that MT-MMP-1 is associated with the activation of progelatinase A in these tumor tissues. The expression of MT-MMP-1 also induced binding of gelatinase A to the cell surface by functioning as a receptor. The cell surface localization of proteinases has advantages over pericellular proteolysis. MT-MMP -1 and its family may play a central role in the cell surface localization and activation of progelatinase A and via this mechanism, tumor cell use exogenous progelatinase A to mediate the proteolysis associated with invasion and metastasis. © by the Journal of Biochemistry Jb Reviews nationallicence gelatinase A nationallicence gelatinase A activator nationallicence matrix metalloproteinase nationallicence MT-MMP nationallicence tumor metastasis nationallicence Sato Hiroshi Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa 920 aut Seiki Motoharu Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa 920 aut The Journal of Biochemistry Oxford University Press 119/2(1996-02), 209-215 0021-924X 119:2<209 1996 119 jbchem https://doi.org/10.1093/oxfordjournals.jbchem.a021223 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jbchem.a021223 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sato Hiroshi Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa 920 aut NATIONALLICENCE 700 1- Seiki Motoharu Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa 920 aut NATIONALLICENCE 773 0- The Journal of Biochemistry Oxford University Press 119/2(1996-02), 209-215 0021-924X 119:2<209 1996 119 jbchem Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford