caa a22 4500 39755642X CHVBK 20180308164803.0 cr unu---uuuuu 161202e199609 xx s 000 0 eng 10.1093/oxfordjournals.jbchem.a021434 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jbchem.a021434 Genomic Imprinting: Significance in Development and Diseases and the Molecular Mechanisms [Elektronische Daten] [Mitsuyoshi Nakao, Hiroyuki Sasaki] Certain mammalian genes are expressed exclusively from either the paternal or the maternal chromosome because of a differential marking process that occurs during gametogenesis. This epigenetic marking is called genomic imprinting. Monoallelic expression of imprinted genes is responsible for the inability of uniparental mammalian embryos to develop normally and for the abnormal phenotypes observed with particular chromosomal disomies. Many of the imprinted genes identified to date are involved in the regulation of cell proliferation and differentiation and, together with other pieces of evidence, they are suggested to play a role in tumorigenesis. Here we discuss how imprinted genes cause diseases and tumors and summarize the recent advances of studies on the molecular basis of this epigenetic phenomenon. In particular, we focus on two wellcharacterized imprinted chromosomal regions, namely the human Prader-Willi/Angelman syndrome region and the mouse INS2/IGF2/H19 region. The correlations between the differential gene activity and the changes in DNA methylation, higher order chromatin structure and replication timing, will shed light on gene regulation at the level of the chromosomal domain. © 1996 BY THE JOURNAL OF BIOCHEMISTRY JB Review nationallicence chromosomal domain nationallicence DNA methylation nationallicence loss of imprinting nationallicence replication timing nationallicence uniparental disomy nationallicence Nakao Mitsuyoshi Department of Tumor Genetics and Biology, Kumamoto University School of Medicine 2-2-1 Honjo, Kumamoto 860 aut Sasaki Hiroyuki Institute of Genetic Information, Kyushu University 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-82 aut The Journal of Biochemistry Oxford University Press 120/3(1996-09), 467-473 0021-924X 120:3<467 1996 120 jbchem https://doi.org/10.1093/oxfordjournals.jbchem.a021434 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jbchem.a021434 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakao Mitsuyoshi Department of Tumor Genetics and Biology, Kumamoto University School of Medicine 2-2-1 Honjo, Kumamoto 860 aut NATIONALLICENCE 700 1- Sasaki Hiroyuki Institute of Genetic Information, Kyushu University 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-82 aut NATIONALLICENCE 773 0- The Journal of Biochemistry Oxford University Press 120/3(1996-09), 467-473 0021-924X 120:3<467 1996 120 jbchem Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford