caa a22 4500 397556594 CHVBK 20180308164804.0 cr unu---uuuuu 161202e199609 xx s 000 0 eng 10.1093/oxfordjournals.jbchem.a021460 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jbchem.a021460 Nakano Akihiko Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113 Identification and Characterization of Extragenic Suppressors of the Yeast sec 12 ts Mutation [Elektronische Daten] [Akihiko Nakano] The product of the yeast SEC12 gene is the most upstream player as far as we know in the events of vesicle budding from the endoplasmic reticulum membrane. To understand how the Sec12p function could be regulated, I identified three extragenic suppressor mutations of the sec12 ts mutation. RST1DS is a dominant mutation and causes elevated expression of Sec12p. rst2 and rst3 are recessive and give pleiotropic phenotypes including slow growth at low temperatures and heterogeneous modification of Secl2p. Their possible roles are discussed. © 1996 BY THE JOURNAL OF BIOCHEMISTRY Regular Papers nationallicence endoplasmic reticulum nationallicence RST nationallicence Saccharomyces cerevisiae nationallicence SEC12 nationallicence vesicular transport nationallicence The Journal of Biochemistry Oxford University Press 120/3(1996-09), 642-646 0021-924X 120:3<642 1996 120 jbchem https://doi.org/10.1093/oxfordjournals.jbchem.a021460 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jbchem.a021460 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Nakano Akihiko Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113 NATIONALLICENCE 773 0- The Journal of Biochemistry Oxford University Press 120/3(1996-09), 642-646 0021-924X 120:3<642 1996 120 jbchem Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford