caa a22 4500 397556640 CHVBK 20180308164804.0 cr unu---uuuuu 161202e199608 xx s 000 0 eng 10.1093/oxfordjournals.jbchem.a021405 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jbchem.a021405 Nutritional Regulation of Lipogenic Enzyme Gene Expression in Rat Epididymal Adipose Tissue [Elektronische Daten] [Nobuko Iritani, Hitomi Fukuda, Kayoko Tada] The time courses of gene expression, and the nutritional regulation of gene expression of lipogenic enzymes (acetyl-CoA carboxylase, fatty acid synthase, ATP citrate-lyase, malic enzyme, and glucose-6-phosphate dehydrogenase) in epididymal adipose tissue after refeeding food-deprived rats have been investigated and compared with those in liver (previously reported). The mRNA concentrations of lipogenic enzymes reached maximum levels at 24 h after the refeeding in adipose tissue and at 8-16 h in liver, while the enzyme induction reached maximum at 48-72 h in both tissues. Moreover, the mRNAs were more strongly induced in adipose tissue than in liver, whereas the enzyme induction (except malic enzyme) was lower. In adipose tissue of rats fed a carbohydrate diet without protein, the mRNA concentrations of acetyl-CoA carboxylase, ATP-citrate lyase, malic enzyme, and fatty acid synthase reached comparable levels to those of the carbohydrate/protein diet group. The protein feeding increased the enzyme induction in adipose tissue. As regards reduction of gene expression, lipogenic enzyme mRNA concentrations were not so markedly reduced by starvation or polyunsaturated fatty acids in adipose tissue as in liver. The differences in regulation of lipogenic enzyme gene expression and induction between adipose tissue and liver can be ascribed to tissue specificity. © 1996 BY THE JOURNAL OF BIOCHEMISTRY Regular Papers nationallicence adipose tissue nationallicence lipogenic enzyme gene expression nationallicence nutritional regulation nationallicence Iritani Nobuko Tezukayama Gakuin College, Sakai, Osaka 590-01 aut Fukuda Hitomi Tezukayama Gakuin College, Sakai, Osaka 590-01 aut Tada Kayoko Tezukayama Gakuin College, Sakai, Osaka 590-01 aut The Journal of Biochemistry Oxford University Press 120/2(1996-08), 242-248 0021-924X 120:2<242 1996 120 jbchem https://doi.org/10.1093/oxfordjournals.jbchem.a021405 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jbchem.a021405 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Iritani Nobuko Tezukayama Gakuin College, Sakai, Osaka 590-01 aut NATIONALLICENCE 700 1- Fukuda Hitomi Tezukayama Gakuin College, Sakai, Osaka 590-01 aut NATIONALLICENCE 700 1- Tada Kayoko Tezukayama Gakuin College, Sakai, Osaka 590-01 aut NATIONALLICENCE 773 0- The Journal of Biochemistry Oxford University Press 120/2(1996-08), 242-248 0021-924X 120:2<242 1996 120 jbchem Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford