caa a22 4500 397556721 CHVBK 20180308164804.0 cr unu---uuuuu 161202e199608 xx s 000 0 eng 10.1093/oxfordjournals.jbchem.a021409 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jbchem.a021409 Expression of Inter-α-Trypsin Inhibitor Light Chain (Bikunin) in Human Pancreas [Elektronische Daten] [Hiroshi Itoh, Masaki Tomita, Takahiko Kobayashi, Hirofumi Uchino, Haruhiko Maruyama, Yukifumi Nawa] Expression of inter-α-trypsin inhibitor light chain (ITI-LC, also known as bikunin or urinary trypsin inhibitor) was examined in various human tissues. By reverse-transcription polymerase chain reaction, the mRNA was detected not only in the liver, a known site of ITI-LC production, but also in the kidney, heart, lung, and pancreas. By RNA blot analysis, the mRNA was also detected in the pancreas and liver, but not in the kidney, heart, or lung. The ITI-LC protein was immunohistochemically detected along the surface of pancreatic acinar cells. These results indicate the apparent expression of the gene for ITI-LC in the pancreas. ITI-LC protein on the surface of pancreatic acinar cells may play an important role in preventing autodigestion by exocrine enzymes such as trypsinogen and chymotrypsinogen. © 1996 BY THE JOURNAL OF BIOCHEMISTRY Regular Papers nationallicence bikunin nationallicence human nationallicence inter-α-trypsin inhibitor light chain nationallicence pancreas nationallicence urinary trypsin inhibitor (UTI) nationallicence Itoh Hiroshi Department of Parasitology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-16 aut Tomita Masaki Department of Parasitology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-16 aut Kobayashi Takahiko Department of Parasitology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-16 aut Uchino Hirofumi Department of Parasitology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-16 aut Maruyama Haruhiko Department of Parasitology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-16 aut Nawa Yukifumi Department of Parasitology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-16 aut The Journal of Biochemistry Oxford University Press 120/2(1996-08), 271-275 0021-924X 120:2<271 1996 120 jbchem https://doi.org/10.1093/oxfordjournals.jbchem.a021409 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jbchem.a021409 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Itoh Hiroshi Department of Parasitology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-16 aut NATIONALLICENCE 700 1- Tomita Masaki Department of Parasitology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-16 aut NATIONALLICENCE 700 1- Kobayashi Takahiko Department of Parasitology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-16 aut NATIONALLICENCE 700 1- Uchino Hirofumi Department of Parasitology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-16 aut NATIONALLICENCE 700 1- Maruyama Haruhiko Department of Parasitology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-16 aut NATIONALLICENCE 700 1- Nawa Yukifumi Department of Parasitology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-16 aut NATIONALLICENCE 773 0- The Journal of Biochemistry Oxford University Press 120/2(1996-08), 271-275 0021-924X 120:2<271 1996 120 jbchem Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford