caa a22 4500 397556764 CHVBK 20180308164804.0 cr unu---uuuuu 161202e199608 xx s 000 0 eng 10.1093/oxfordjournals.jbchem.a021400 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jbchem.a021400 RCC1 in the Ran Pathway [Elektronische Daten] [Takashi Seki, Naoyuki Hayashi, Takeharu Nishimoto] RCC1 is a chromosomal protein that functions as a GEF of the nuclear G protein Ran, which GTPase activity is enhanced by RNA1 located in the cytoplasm. RCC1 has no preference for GTP or GDP-bound Ran, so that GTP-Ran formation in vivo is regulated by relative concentrations of GTP/GDP and regulatory proteins interacting with RCC1, Ran, and RNA1. Proteins possessing the special Ran-binding motif have been found to be conserved in species ranging from yeasts to mammalians. The finding of RanBP2/NUP358 clearly indicates the involvement of the Ran pathway in the nuclear pore transport function, in agreement with the finding that both rcc1− and rna1− show defects in this process. However, loss of RCC1 induces premature initiation of mitosis, resulting in G1 arrest with the micronuclei possessing mitotic condensed chromosomes. How both the cell cycle and nucleocytoplasmic transport are regulated by the RCC1-Ran pathway is a major question. © 1996 BY THE JOURNAL OF BIOCHEMISTRY JB Reviews nationallicence Ran nationallicence RanBP1 nationallicence RanBP2 nationallicence RCC1 nationallicence RNA1 nationallicence Seki Takashi Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812 aut Hayashi Naoyuki Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812 aut Nishimoto Takeharu Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812 aut The Journal of Biochemistry Oxford University Press 120/2(1996-08), 207-214 0021-924X 120:2<207 1996 120 jbchem https://doi.org/10.1093/oxfordjournals.jbchem.a021400 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jbchem.a021400 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Seki Takashi Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812 aut NATIONALLICENCE 700 1- Hayashi Naoyuki Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812 aut NATIONALLICENCE 700 1- Nishimoto Takeharu Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812 aut NATIONALLICENCE 773 0- The Journal of Biochemistry Oxford University Press 120/2(1996-08), 207-214 0021-924X 120:2<207 1996 120 jbchem Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford