caa a22 4500 397557426 CHVBK 20180308164806.0 cr unu---uuuuu 161202e199604 xx s 000 0 eng 10.1093/oxfordjournals.jbchem.a021283 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jbchem.a021283 Emerging Multipotent Aspects of Hepatocyte Growth Factor [Elektronische Daten] [Kunio Matsumoto, Toshikazu Nakamura] Specific tissue interactions between epithelia and mesenchyme (or stroma), e.g., epithelial-mesenchymal (or -stromal) interactions mediate crucial aspects of normal development and tissue regeneration. These events affect tissue induction, organogenesis, cell movement, and morphogenesis of multicellular structures. Extensive and diverse studies have established that hepatocyte growth factor (HGF), a ligand for the c-met protooncogene product of receptor tyrosine kinase, is a mesenchymal- or stromal-derived multipotent polypeptide which mediates epithelial-mesenchymal interactions. During embryogenesis, HGF supports organogenesis and morphogenesis of various tissues and organs, including the liver, kidney, lung, gut, mammary gland, tooth, skeletal system, etc. In adult tissues, HGF elicits a potent organotrophic function which supports regeneration of organs including the liver, kidney, and lung. In the brain, HGF is a new member of the family of neurotrophic factors. In neoplastic tissue, HGF is involved in tumor invasion and metastasis, through tumor-stromal interactions. While HGF was originally identified as a potent mitogen for mature hepatocytes, the biological functions of this factor reach far beyond the original identifications. Such being the case, use of HGF for purposes of therapeutics is being given increasing attention. © by the Journal of Biochemistry JB Review nationallicence c-met nationallicence epithelial-mesenchymal interactions nationallicence HGF nationallicence morphogenesis nationallicence organogenesis nationallicence organ regeneration nationallicence Matsumoto Kunio Division of Biochemistry, Biomedical Research Center, Osaka University Medical School, Suita, Osaka 565 aut Nakamura Toshikazu Division of Biochemistry, Biomedical Research Center, Osaka University Medical School, Suita, Osaka 565 aut The Journal of Biochemistry Oxford University Press 119/4(1996-04), 591-600 0021-924X 119:4<591 1996 119 jbchem https://doi.org/10.1093/oxfordjournals.jbchem.a021283 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jbchem.a021283 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matsumoto Kunio Division of Biochemistry, Biomedical Research Center, Osaka University Medical School, Suita, Osaka 565 aut NATIONALLICENCE 700 1- Nakamura Toshikazu Division of Biochemistry, Biomedical Research Center, Osaka University Medical School, Suita, Osaka 565 aut NATIONALLICENCE 773 0- The Journal of Biochemistry Oxford University Press 119/4(1996-04), 591-600 0021-924X 119:4<591 1996 119 jbchem Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford