caa a22 4500 397558198 CHVBK 20180308164809.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/oxfordjournals.jbchem.a021252 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jbchem.a021252 Human Tumor Rejection Antigens MAGE [Elektronische Daten] [Kyogo Itoh, Akihiro Hayashi, Masanobu Nakao, Tomoaki Hoshino, Naoko Seki, Shigeki Shichijo] Characterization of the MAGE genes has facilitated a molecular approach to identification of the genes encoding tumor-rejection antigens expressed on human cancer cells. MAGE proteins are normal tissue antigens compartmentalized in testicular cells that play an important role in the early phase of spermatogenesis. MAGE−1, −2, −3, −4, and −6 genes are preferentially expressed in many different cancers at both the mRNA and protein levels. More than half of human cancers of various histologic type express at least one of these MAGE genes. Demethylation induces MAGE antigens in cells, suggesting that MAGE genes are important developmentally regulated genes under methylating control. Thus, genetic instability in cells causing loss of this methylating control could result in the preferential expression of MAGE genes in cancer cells. Therefore, MAGE gene products may be appropriate target molecules for development of new cancer vaccine. © by the Journal of Biochemistry JB Reviews nationallicence human cancer nationallicence MAGE nationallicence peptide antigen nationallicence specific immunity nationallicence tumor-rejection antigen nationallicence Itoh Kyogo Departments of Immunology, Kurume University School of Medicine 67 Asahi-machi, Kurume, Fukuoka 830 aut Hayashi Akihiro Departments of Surgery, Kurume University School of Medicine 67 Asahi-machi, Kurume, Fukuoka 830 aut Nakao Masanobu Departments of Immunology, Kurume University School of Medicine 67 Asahi-machi, Kurume, Fukuoka 830 aut Hoshino Tomoaki Departments of Immunology, Kurume University School of Medicine 67 Asahi-machi, Kurume, Fukuoka 830 aut Seki Naoko Departments of Immunology, Kurume University School of Medicine 67 Asahi-machi, Kurume, Fukuoka 830 aut Shichijo Shigeki Departments of Immunology, Kurume University School of Medicine 67 Asahi-machi, Kurume, Fukuoka 830 aut The Journal of Biochemistry Oxford University Press 119/3(1996-03), 385-390 0021-924X 119:3<385 1996 119 jbchem https://doi.org/10.1093/oxfordjournals.jbchem.a021252 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jbchem.a021252 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Itoh Kyogo Departments of Immunology, Kurume University School of Medicine 67 Asahi-machi, Kurume, Fukuoka 830 aut NATIONALLICENCE 700 1- Hayashi Akihiro Departments of Surgery, Kurume University School of Medicine 67 Asahi-machi, Kurume, Fukuoka 830 aut NATIONALLICENCE 700 1- Nakao Masanobu Departments of Immunology, Kurume University School of Medicine 67 Asahi-machi, Kurume, Fukuoka 830 aut NATIONALLICENCE 700 1- Hoshino Tomoaki Departments of Immunology, Kurume University School of Medicine 67 Asahi-machi, Kurume, Fukuoka 830 aut NATIONALLICENCE 700 1- Seki Naoko Departments of Immunology, Kurume University School of Medicine 67 Asahi-machi, Kurume, Fukuoka 830 aut NATIONALLICENCE 700 1- Shichijo Shigeki Departments of Immunology, Kurume University School of Medicine 67 Asahi-machi, Kurume, Fukuoka 830 aut NATIONALLICENCE 773 0- The Journal of Biochemistry Oxford University Press 119/3(1996-03), 385-390 0021-924X 119:3<385 1996 119 jbchem Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford