caa a22 4500 397558260 CHVBK 20180308164809.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/oxfordjournals.jbchem.a021253 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jbchem.a021253 Hayatsu Hikoya Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700 The 5,6-Double Bond of Pyrimidine Nucleosides, a Fragile Site in Nucleic Acids [Elektronische Daten] [Hikoya Hayatsu] Our studies have revealed reagents that can attack the 5,6-double bond of pyrimidine nucleosides; potassium permanganate and bisulfite. This review is a personal account of these studies, with a discussion on the vulnerable nature of this particular double bond to external nucleophiles and oxidizing agents. The finding that N(4)aminocytidine, produced on treatment of cytidine with bisulfite and hydrazine, is a strong mutagen is also described. © by the Journal of Biochemistry JB Reviews nationallicence N(4)aminocytidine nationallicence bisulfite nationallicence ermanganate nationallicence pyrimidine nucleotides nationallicence The Journal of Biochemistry Oxford University Press 119/3(1996-03), 391-395 0021-924X 119:3<391 1996 119 jbchem https://doi.org/10.1093/oxfordjournals.jbchem.a021253 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jbchem.a021253 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hayatsu Hikoya Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700 NATIONALLICENCE 773 0- The Journal of Biochemistry Oxford University Press 119/3(1996-03), 391-395 0021-924X 119:3<391 1996 119 jbchem Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford