caa a22 4500 397561024 CHVBK 20180308164816.0 cr unu---uuuuu 161202e19960417xx s 000 0 eng 10.1093/jnci/88.8.496 doi (NATIONALLICENCE)oxford-10.1093/jnci/88.8.496 Perera Frederica P. Molecular Epidemiology: Insights Into Cancer Susceptibility, Risk Assessment, and Prevention [Elektronische Daten] [Frederica P. Perera] Recent molecular epidemiologic research provides compelling new evidence that environmental factors are major contributors to human cancer and that their risks are strongly influenced by genetic and aquired susceptibility. In particular, molecular epidemiology has demonstrated substantial variability in biologic response to carcinogens and suggests that certain groups—such as the very young, those with predisposing genetic traits or nutritional deficits, and even certain ethnic groups—are likely to have greater risk from selected exposures than other members of the population. This work implies that major gains in prevention of cancer, which will claim more than 554 000 American lives this year, will necessitate health and regulatory policies that protect these more susceptible groups and individuals from risks of man-made and naturally occurring environmental carcinogens. The specific implication from this research is that, to be effective in prevention, risk assessments developed in support of these policies by regulatory bodies, such as the Environmental Protection Agency, should reflect the available scientific data on individual variability in both exposure and susceptibility. [J Natl Cancer Inst 1996; 88: 496-509] © Oxford University Press REVIEW nationallicence JNCI: Journal of the National Cancer Institute Oxford University Press 88/8(1996-04-17), 496-509 0027-8874 88:8<496 1996 88 jnci https://doi.org/10.1093/jnci/88.8.496 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jnci/88.8.496 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Perera Frederica P. NATIONALLICENCE 773 0- JNCI: Journal of the National Cancer Institute Oxford University Press 88/8(1996-04-17), 496-509 0027-8874 88:8<496 1996 88 jnci Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford