caa a22 4500 397561229 CHVBK 20180308164816.0 cr unu---uuuuu 161202e19960306xx s 000 0 eng 10.1093/jnci/88.5.240 doi (NATIONALLICENCE)oxford-10.1093/jnci/88.5.240 Rhyu Michelle S. M. S. Rhyu, Ph.D., was a Technology Transfer Fellow at the Journal of the National Cancer Institute, National Cancer Institute Bethesda, MD when this article was written. Molecular Mechanisms Underlying Hereditary Nonpolyposis Colorectal Carcinoma [Elektronische Daten] [Michelle S. Rhyu] MutS and MutL are bacterial genes that have critical roles in DNA repair and recombination. Mutations in homologues of these genes cause hereditary nonpolyposis colorectal carcinoma and are implicated in some sporadic (nonhereditary) colorectal cancers. Molecular functions of these genes have been defined through extensive work in bacteria and yeast. This article reviews and explores molecular events that require MutS and MutL, including mismatch repair, homologous recombination, and gense conversion. The mechanisms of action of eukaryotic MutS and MutL homologues are compared with those of their prokaryotic counterparts, and the relevance of these mechanisms to tumorigenesis is discussed. [J Natl Cancer Inst 1996;88:240-51] © Oxford University Press SPECIAL ARTICLE nationallicence JNCI: Journal of the National Cancer Institute Oxford University Press 88/5(1996-03-06), 240-251 0027-8874 88:5<240 1996 88 jnci https://doi.org/10.1093/jnci/88.5.240 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jnci/88.5.240 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Rhyu Michelle S. M. S. Rhyu, Ph.D., was a Technology Transfer Fellow at the Journal of the National Cancer Institute, National Cancer Institute Bethesda, MD when this article was written NATIONALLICENCE 773 0- JNCI: Journal of the National Cancer Institute Oxford University Press 88/5(1996-03-06), 240-251 0027-8874 88:5<240 1996 88 jnci Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford