caa a22 4500 397563507 CHVBK 20180308164822.0 cr unu---uuuuu 161202e19961016xx s 000 0 eng 10.1093/jnci/88.20.1442 doi (NATIONALLICENCE)oxford-10.1093/jnci/88.20.1442 Harris Curtis C. Laboratory of Human Carcinogenesis, Division of Basic Science, National Cancer Institute, Bethesda, MD Structure and Function of the p53 Tumor Suppressor Gene: Clues for Rational Cancer Therapeutic Strategies [Elektronische Daten] [Curtis C. Harris] The p53 tumor suppressor protein is involved in multiple central cellular processes, including transcription, DNA repair, genomic stability, senescence, cell cycle control, and apoptosis. p53 is functionally inactivated by structural mutations, interaction with viral products, and endogenous cellular mechanisms in the majority of human cancers. This functional inactivation can, in some circumstances, produce resistance to DNA-damaging agents commonly used in cancer chemotherapy and radiotherapeutic approaches. Current research is defining the biochemical pathways through which p53 induces cell cycle arrest and apoptosis. Knowledge of these fundamental processes is leading to the identification of molecular targets toward which multimodality cancer therapies, using chemotherapeutic, immunotherapeutic, and gene-therapeutic strategies, can be based. © Oxford University Press REVIEW nationallicence JNCI: Journal of the National Cancer Institute Oxford University Press 88/20(1996-10-16), 1442-1455 0027-8874 88:20<1442 1996 88 jnci https://doi.org/10.1093/jnci/88.20.1442 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jnci/88.20.1442 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Harris Curtis C. Laboratory of Human Carcinogenesis, Division of Basic Science, National Cancer Institute, Bethesda, MD NATIONALLICENCE 773 0- JNCI: Journal of the National Cancer Institute Oxford University Press 88/20(1996-10-16), 1442-1455 0027-8874 88:20<1442 1996 88 jnci Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford