caa a22 4500 397566026 CHVBK 20180308164828.0 cr unu---uuuuu 161202e19961002xx s 000 0 eng 10.1093/jnci/88.19.1346 doi (NATIONALLICENCE)oxford-10.1093/jnci/88.19.1346 DNA Repair: Enzymatic Mechanisms and Relevance to Drug Response [Elektronische Daten] [Stephen G. Chaney, Aziz Sancar] A number of chemotherapeutic agents, such as platinum drugs, nitrogen mustards, and chloroethylnitrosoureas, act by forming bifunctional DNA adducts. It is likely that abortive attempts to replicate and/or repair the damaged DNA cause chromosome aberrations and breakage, leading to cell death. Any substantial increase in cellular capacity to repair damaged DNA may result in resistance to chemotherapeutic agents. In this review, we examine the types of DNA adducts formed by the major classes of chemotherapeutic agents, the enzymatic pathways that play a role in the repair of those adducts, the evidence that DNA repair is enhanced in drug-resistant cell lines and tumors, and strategies for utilizing selective inhibition of DNA repair to overcome resistance. © Oxford University Press REVIEW nationallicence Chaney Stephen G. Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill aut Sancar Aziz Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill aut JNCI: Journal of the National Cancer Institute Oxford University Press 88/19(1996-10-02), 1346-1360 0027-8874 88:19<1346 1996 88 jnci https://doi.org/10.1093/jnci/88.19.1346 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jnci/88.19.1346 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chaney Stephen G. Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill aut NATIONALLICENCE 700 1- Sancar Aziz Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill aut NATIONALLICENCE 773 0- JNCI: Journal of the National Cancer Institute Oxford University Press 88/19(1996-10-02), 1346-1360 0027-8874 88:19<1346 1996 88 jnci Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford