caa a22 4500 397566840 CHVBK 20180308164830.0 cr unu---uuuuu 161202e199611 xx s 000 0 eng 10.3382/ps.0751417 doi (NATIONALLICENCE)oxford-10.3382/ps.0751417 Independent and Simultaneous Unilateral Occlusion of the Pulmonary Artery and Extra-Pulmonary Primary Bronchus in Broilers [Elektronische Daten] [ROBERT F. WIDEMAN, YVONNE KOCHERA KIRBY, CAYE D. TACKETT, NATHAN E. MARSON, CORINNA J. TRESSLER, RONALD W. MCNEW] Acutely tightening a snare around one pulmonary artery previously was shown to trigger a reversible ventilation-perfusion (V̇/Q̇) mismatch in broilers, as reflected by decreases in the partial pressure of oxygen in arterial blood (hypoxemia), accompanied by increases in the hydrogen ion concentration (acidosis) and partial pressure of carbon dioxide (hypercapnia). In the present study, snares were loosely implanted around the right pulmonary artery and the right extra-pulmonary primary bronchus in anesthetized male broilers. These snares were tightened and released independently and then simultaneously to evaluate the possibility that directing the entire respiratory minute volume toward the left lung might attenuate the V̇/Q̇ mismatch caused by forcing the entire cardiac output (CO) through the left lung. Fully reversible arterial blood hypoxemia, acidosis, and hypercapnia occurred when either snare was tightened independently. Presumably, tightening the bronchial snare restricted ventilation but not blood flow to the right lung, thereby permitting blood to perfuse poorly ventilated gas exchange surfaces. Simultaneously tightening both snares triggered arterial blood hypoxemia, acidosis, and hypercapnia similar to or greater in magnitude than the responses obtained by tightening the pulmonary artery snare independently. Tightening either snare independently or both snares simultaneously caused pulmonary arterial pressure to increase (pulmonary hypertension), and permanent obstruction of one bronchus in a separate experiment caused an increase in the right:total ventricular weight ratio, which is indicative of chronic pulmonary hypertension. The mean systemic arterial pressure decreased when the pulmonary artery snare was tightened independently or in combination with the bronchial snare, but not when the bronchial snare was tightened independently. The respiratory rate increased and the heart rate decreased when the pulmonary artery snare was tightened independently, but not when the bronchial snare was tightened independently or in combination with the pulmonary artery snare. These results demonstrate that the V̇/Q̇ mismatch caused by forcing all the CO to perfuse one lung cannot be attenuated by simultaneously directing the entire respiratory minute volume toward the same lung. © 1996 Poultry Science Association, Inc. Physiology and Reproduction nationallicence ascites nationallicence pulmonary hypertension nationallicence respiration nationallicence blood pressure nationallicence acidosis nationallicence ventilation-perfusion inequality nationallicence WIDEMAN ROBERT F. Department of Poultry Science and aut KIRBY YVONNE KOCHERA Department of Poultry Science and aut TACKETT CAYE D. Department of Poultry Science and aut MARSON NATHAN E. Department of Poultry Science and aut TRESSLER CORINNA J. Department of Poultry Science and aut MCNEW RONALD W. Agricultural Statistics Laboratory, University of Arkansas, Fayetteville, Arkansas 72701 aut Poultry Science Oxford University Press 75/11(1996-11), 1417-1427 0032-5791 75:11<1417 1996 75 ps https://doi.org/10.3382/ps.0751417 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.3382/ps.0751417 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- WIDEMAN ROBERT F. Department of Poultry Science and aut NATIONALLICENCE 700 1- KIRBY YVONNE KOCHERA Department of Poultry Science and aut NATIONALLICENCE 700 1- TACKETT CAYE D. Department of Poultry Science and aut NATIONALLICENCE 700 1- MARSON NATHAN E. Department of Poultry Science and aut NATIONALLICENCE 700 1- TRESSLER CORINNA J. Department of Poultry Science and aut NATIONALLICENCE 700 1- MCNEW RONALD W. Agricultural Statistics Laboratory, University of Arkansas, Fayetteville, Arkansas 72701 aut NATIONALLICENCE 773 0- Poultry Science Oxford University Press 75/11(1996-11), 1417-1427 0032-5791 75:11<1417 1996 75 ps Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford