caa a22 4500 397566999 CHVBK 20180308164830.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.3382/ps.0750648 doi (NATIONALLICENCE)oxford-10.3382/ps.0750648 BURKE W. H. Department of Poultry Science, The University of Georgia, Athens, Georgia 30602-2772 Effects of an In Ovo Injection of an Anti-Androgen on Embryonic and Posthatching Growth of Broiler Chicks [Elektronische Daten] [W. H. BURKE] Experiments were conducted to determine whether in ovo injection of Flutamide®, a non-steroidal anti-androgen, would affect posthatching growth of broiler chickens. Before doing these studies it was necessary to develop a bioassay to demonstrate that Flutamide® had anti-androgenic actions when injected in ovo. In ovo injection of 0.06 to 1.74 μmol of testosterone propionate (TP) per egg on the 8th d of incubation caused a dose-related decrease in weight of the bursa of Fabricius of newly hatched chicks. In subsequent experiments, 1.74 μmol of Flutamide® significantly decreased the bursal regression produced by 0.58 μmol of TP when both substances were injected on Day 8 of incubation and bursal weights were taken on the day of hatch. Having established that Flutamide® could block the effects of high doses of exogenous TP, it was reasoned that it could block the action of much lower endogenous levels. In two of the three experiments, injection of Flutamide® on the 8th d of incubation resulted in a dose-related decrease in 21- and 49-d BW of male broiler chickens. The material had no effect on BW of males in one experiment and had no effect on BW of females at any age in any of the experiments. The data suggest that interference with the actions of endogenous androgens during embryonic life suppresses the posthatching growth of male broilers. © 1996 Poultry Science Association, Inc. Physiology and Reproduction nationallicence androgen nationallicence antiandrogen nationallicence Flutamide® nationallicence growth nationallicence chicken nationallicence Poultry Science Oxford University Press 75/5(1996-05), 648-655 0032-5791 75:5<648 1996 75 ps https://doi.org/10.3382/ps.0750648 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.3382/ps.0750648 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- BURKE W. H. Department of Poultry Science, The University of Georgia, Athens, Georgia 30602-2772 NATIONALLICENCE 773 0- Poultry Science Oxford University Press 75/5(1996-05), 648-655 0032-5791 75:5<648 1996 75 ps Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford