caa a22 4500 397567138 CHVBK 20180308164831.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.3382/ps.0750432 doi (NATIONALLICENCE)oxford-10.3382/ps.0750432 Inhibition by Aminoguanidine of Glucose-Derived Collagen Cross-Linking in Skeletal Muscle of Broiler Breeder Hens [Elektronische Daten] [H. KLANDORF, Q. ZHOU, A. R. SAMS] Aminoguanidine (AG) is a nucleophilic compound that inhibits nonenzymatic, glucose-derived collagen cross-linking in animal tissues. Whether AG can attenuate the accumulation of collagen cross-links in the Biceps femoris muscle of 64-wk-old broiler breeder hens as well as improve meat quality, was investigated. Eighty-four broiler breeder hens (30-wk-old) were divided into four equal groups. Each group was assigned randomly to diets supplemented with 0, 200, 400, or 800 ppm AG, respectively. Birds were fed individually, 150 g diet/d. After feeding AG for 34 wk, six birds from each group were killed and samples from the leg muscle were analyzed for changes in collagen content. Aminoguanidine decreased (P < 0.05) glucose-derived collagen cross-links in skeletal muscle as measured by fluorescence and collagen solubility. Insoluble collagen fraction decreased with increasing AG dosage, whereas acid-soluble and pepsin-soluble fractions increased with increasing AG dosage. Amino-guanidine did not affect shear force. In agreement with studies on animals with diabetes, AG is a potent inhibitor of glucose-derived cross-linking in chickens, although the results from the measurements of shear force do not support its use for improving carcass quality in spent hens. © 1996 Poultry Science Association, Inc. Processing and Products nationallicence broiler breeder hen nationallicence aminoguanidine nationallicence nonenzymatic collagen cross-linking nationallicence meat tenderness nationallicence tissue fluorescence nationallicence KLANDORF H. Division of Animal and Veterinary Sciences, West Virginia University, Morgantown, West Virginia 26506-6108 aut ZHOU Q. Division of Animal and Veterinary Sciences, West Virginia University, Morgantown, West Virginia 26506-6108 aut SAMS A. R. Department of Poultry Science, Texas A&M University, College Station, Texas 77843-2472 aut Poultry Science Oxford University Press 75/3(1996-03), 432-437 0032-5791 75:3<432 1996 75 ps https://doi.org/10.3382/ps.0750432 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.3382/ps.0750432 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- KLANDORF H. Division of Animal and Veterinary Sciences, West Virginia University, Morgantown, West Virginia 26506-6108 aut NATIONALLICENCE 700 1- ZHOU Q. Division of Animal and Veterinary Sciences, West Virginia University, Morgantown, West Virginia 26506-6108 aut NATIONALLICENCE 700 1- SAMS A. R. Department of Poultry Science, Texas A&M University, College Station, Texas 77843-2472 aut NATIONALLICENCE 773 0- Poultry Science Oxford University Press 75/3(1996-03), 432-437 0032-5791 75:3<432 1996 75 ps Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford