caa a22 4500 397568096 CHVBK 20180308164833.0 cr unu---uuuuu 161202e199601 xx s 000 0 eng 10.3382/ps.0750029 doi (NATIONALLICENCE)oxford-10.3382/ps.0750029 The Influence of Major Histocompatibility Complex Genotypes on Resistance to Pasteurella multocida and Newcastle Disease Virus in Turkeys [Elektronische Daten] [K. E. NESTOR, Y. M. SAIF, J. ZHU, D. O. NOBLE, R. A. PATTERSON] Sublines homozygous for each of four MHC haplotypes were developed from randombred control populations of turkeys and challenged with Pasteurella multocida (capsular serogroup a, somatic serotype 3, 4) at 6 wk of age or Newcastle disease virus (NDV; Texas GB strain) at 4 wk of age. In addition, individuals from a randombred control line (RBC2) and a subline (F) of RBC2 long-term selected for increased 16-wk BW were included in most of the challenge trials. The duration of the challenge trials was 2 wk for both organisms. Mortality following challenge with P. multocida or NDV was higher in the F line than in its randombred control. The MHC genotypes differed in mortality following exposure to both organisms but the rankings of the genotypes were not the same for P. multocida and NDV. The increased susceptibility of the F line to both organisms could not be explained by known changes in the frequency of the MHC haplotypes. © 1996 Poultry Science Association, Inc. Breeding and Genetics nationallicence major histocompatibility complex nationallicence Pasteurella multocida nationallicence Newcastle disease virus nationallicence disease resistance nationallicence turkey nationallicence NESTOR K. E. Department of Animal Sciences and aut SAIF Y. M. Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio 44691 aut ZHU J. Department of Animal Sciences and aut NOBLE D. O. Department of Animal Sciences and aut PATTERSON R. A. Department of Animal Sciences and aut Poultry Science Oxford University Press 75/1(1996-01), 29-33 0032-5791 75:1<29 1996 75 ps https://doi.org/10.3382/ps.0750029 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.3382/ps.0750029 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- NESTOR K. E. Department of Animal Sciences and aut NATIONALLICENCE 700 1- SAIF Y. M. Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio 44691 aut NATIONALLICENCE 700 1- ZHU J. Department of Animal Sciences and aut NATIONALLICENCE 700 1- NOBLE D. O. Department of Animal Sciences and aut NATIONALLICENCE 700 1- PATTERSON R. A. Department of Animal Sciences and aut NATIONALLICENCE 773 0- Poultry Science Oxford University Press 75/1(1996-01), 29-33 0032-5791 75:1<29 1996 75 ps Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford