caa a22 4500 397568452 CHVBK 20180308164834.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.3382/ps.0750285 doi (NATIONALLICENCE)oxford-10.3382/ps.0750285 Skin Allograft Survival in Chicken Strains with Spontaneous Autoimmune Diseases [Elektronische Daten] [HERMANN M. DIETRICH, ANTONIO J. OLIVEIRA-DOS-SANTOS, KAREL HALA, GEORG WICK] Skin grafts were performed to prove the level of genetic diversity in chicken populations of the Obese strain (OS), which develops a spontaneous Hashimoto's-like thyroiditis, and University of California at Davis (UCD) Line-200 chickens, which are hereditarily afflicted with progressive systemic sclerosis (scleroderma). As controls, Cornell C-strain (CS) and inbred, normal White Leghorn CB chickens were included in the genetic monitoring program. At the commencement of this study in 1988, median allograft rejections were observed after 9 to 12 d (range 8 to 14 d) in OS and CS chickens that derived from large flocks at Cornell University, whereas OS sublines of the smaller, more closely-bred colonies at the University of Innsbruck, Austria, showed median allograft rejection after 19 d (range 12 to 35 d). From 1988 to 1993, allograft survival was only slightly prolonged in the OS sublines. However, the results of the skin allotransplantations in inbred UCD-200 chickens revealed two subpopulations in this line. In one subgroup the median of allograft rejection was calculated with 13 d (range 6 to 37 d) in 1989, 30 d (10 to 37 d) in 1990, 21 d (8 to 90 d) in 1991, and 16 d (7 to 26 d) in 1993. In the other subgroup allografts were accepted at rates similar to autografts. In addition, the inbreeding coefficient was calculated for eight male and eight female OSB 5 B 5Cornell (C) and OSB 5 B 5Innsbruck (INN) chickens, respectively, hatched in 1993. On the basis of mating records, the minimal estimate of the inbreeding coefficient was calculated to be 0.0679 in the OSB 5 B 5C and 0.1035 in the OSB 5 B 5INN population. The results demonstrated a higher degree of consanguinity in the smaller population of OSB 5 B 5INN chickens compared to OSB 5 B 5C birds. The latter are maintained in larger numbers, therefore, the frequency of matings between related individuals should be lower. © 1996 Poultry Science Association, Inc. Breeding and Genetics nationallicence genetic monitoring nationallicence skin allograft survival time nationallicence Obese strain of chickens nationallicence UCD-200 line nationallicence autoimmune diseases nationallicence DIETRICH HERMANN M. Central Laboratory Animal Facilities, and aut OLIVEIRA-DOS-SANTOS ANTONIO J. Institute for General and Experimental Pathology, University of Innsbruck, Medical School, 6020 Innsbruck, Austria aut HALA KAREL Institute for General and Experimental Pathology, University of Innsbruck, Medical School, 6020 Innsbruck, Austria aut WICK GEORG Central Laboratory Animal Facilities, and aut Poultry Science Oxford University Press 75/3(1996-03), 285-293 0032-5791 75:3<285 1996 75 ps https://doi.org/10.3382/ps.0750285 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.3382/ps.0750285 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- DIETRICH HERMANN M. Central Laboratory Animal Facilities, and aut NATIONALLICENCE 700 1- OLIVEIRA-DOS-SANTOS ANTONIO J. Institute for General and Experimental Pathology, University of Innsbruck, Medical School, 6020 Innsbruck, Austria aut NATIONALLICENCE 700 1- HALA KAREL Institute for General and Experimental Pathology, University of Innsbruck, Medical School, 6020 Innsbruck, Austria aut NATIONALLICENCE 700 1- WICK GEORG Central Laboratory Animal Facilities, and aut NATIONALLICENCE 773 0- Poultry Science Oxford University Press 75/3(1996-03), 285-293 0032-5791 75:3<285 1996 75 ps Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford