caa a22 4500 397569165 CHVBK 20180308164836.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.3382/ps.0750388 doi (NATIONALLICENCE)oxford-10.3382/ps.0750388 Effect of Recombinant Human Insulin-Like Growth Factor-II on Weight Gain and Body Composition of Broiler Chickens [Elektronische Daten] [G.S.G. SPENCER, E. DECUYPERE, J. BUYSE, M. ZEMAN] Osmotic minipumps containing either saline or recombinant human insulin-like growth factor-II (IGF-II) were implanted into 4-wk-old female broiler chickens such that the treated chickens received 0.5 mg IGF-II/kg body weight per d. At the end of the trial, no differences in body weight gain or bone length were detected between the treated and control groups. Similarly, there were no differences between the two treatments with respect to heart, spleen, liver, or bursa of Fabricius weight. The relative weight óf the abdominal fat pads was greater (P < 0.05) in the birds treated with IGF-II than in the controls, whereas the weight of breast muscle was reduced (P = 0.06) in the birds treated with IGF-II. There was no effect of IGF-II treatment on feed intake or feed conversion efficiency. Plasma growth hormone (GH) levels were acutely depressed by 15 min after IGF-II administration; and also after 2 wk of IGF-II treatment. Plasma triiodothyronine (T3) concentrations were significantly depressed by IGF-II treatment. These results suggest that IGF-II may not stimulate growth in chickens, but can act as a nutrient partitioning agent, either directly or indirectly through altering plasma GH or T3 concentrations. © 1996 Poultry Science Association, Inc. Physiology and Reproduction nationallicence insulin-like growth factor-II nationallicence chicken nationallicence growth nationallicence body composition nationallicence fat nationallicence SPENCER G.S.G. aut DECUYPERE E. 2To whom correspondence should be addressed. aut BUYSE J. aut ZEMAN M. aut Poultry Science Oxford University Press 75/3(1996-03), 388-392 0032-5791 75:3<388 1996 75 ps https://doi.org/10.3382/ps.0750388 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.3382/ps.0750388 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- SPENCER G.S.G. aut NATIONALLICENCE 700 1- DECUYPERE E. 2To whom correspondence should be addressed aut NATIONALLICENCE 700 1- BUYSE J. aut NATIONALLICENCE 700 1- ZEMAN M. aut NATIONALLICENCE 773 0- Poultry Science Oxford University Press 75/3(1996-03), 388-392 0032-5791 75:3<388 1996 75 ps Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford