caa a22 4500 397569173 CHVBK 20180308164836.0 cr unu---uuuuu 161202e199610 xx s 000 0 eng 10.3382/ps.0751156 doi (NATIONALLICENCE)oxford-10.3382/ps.0751156 Immunoresponsiveness in Chickens: Association of Antibody Production and the B System of the Major Histocompatibility Complex [Elektronische Daten] [E. A. DUNNINGTON, W. E. BRILES, R. W. BRILES, P. B. SIEGEL] Lines of White Leghorn chickens were selected for high or low antibody response to sheep erythrocytes for five generations. The base population from which the experiment started was composed of individuals all of which were heterozygous at the MHC haplotypes B 13 and B 21. Body weights, egg production traits, and genotypes at the B system were monitored for all individuals in each generation. By Generations 4 and 5 there was separation of the two replicate lines selected for high titer from the two replicate lines selected for low titer. Over the course of the experiment, higher antibody titers and lower BW were associated with B 21 and lower antibody titers and higher BW were associated with B 13, although these relationships did not occur in every instance. Conclusions were that the B system was associated with antibody response, but that the chickens did not depend entirely upon that association for protection against foreign proteins. Also, the importance of having replicate lines in a selection experiment was shown. © 1996 Poultry Science Association, Inc. Breeding and Genetics nationallicence Major histocompatibility complex nationallicence antibody nationallicence chicken nationallicence selection nationallicence sheep red blood cells nationallicence DUNNINGTON E. A. Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, Virginia 24061-0306, and aut BRILES W. E. Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115-2854 aut BRILES R. W. Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115-2854 aut SIEGEL P. B. Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, Virginia 24061-0306, and aut Poultry Science Oxford University Press 75/10(1996-10), 1156-1160 0032-5791 75:10<1156 1996 75 ps https://doi.org/10.3382/ps.0751156 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.3382/ps.0751156 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- DUNNINGTON E. A. Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, Virginia 24061-0306, and aut NATIONALLICENCE 700 1- BRILES W. E. Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115-2854 aut NATIONALLICENCE 700 1- BRILES R. W. Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115-2854 aut NATIONALLICENCE 700 1- SIEGEL P. B. Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, Virginia 24061-0306, and aut NATIONALLICENCE 773 0- Poultry Science Oxford University Press 75/10(1996-10), 1156-1160 0032-5791 75:10<1156 1996 75 ps Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford