caa a22 4500 397569203 CHVBK 20180308164836.0 cr unu---uuuuu 161202e199606 xx s 000 0 eng 10.3382/ps.0750705 doi (NATIONALLICENCE)oxford-10.3382/ps.0750705 Effects of Feed Antibiotic Avoparcine on Organ Morphology in Broiler Chickens [Elektronische Daten] [A. L. KRINKE, D. JAMROZ] Groups of 90 male broilers each were administered the antibiotic avoparcine mixed into feed in concentrations of 7.5, 10, and 15 ppm and achieved a higher mean body weight than the controls fed without this admixture. At the end of the 70-d fattening period, histological examination was carried out on selected individuals. The small intestine, liver, bursa of Fabricius, thymus, thyroid gland, pancreas, kidneys, heart, and skeletal muscle were observed on paraffin sections stained with hematoxylin and eosin. Cell proliferation was assessed in the liver and small intestine by means of bromodeoxyuridine labeling. The exposure to avoparcine resulted in a decreased cell proliferation in both tissues when compared to controls. In addition, hypertrophy of the hepatocytes and development of reactive lymphoid tissue in the bursa of Fabricius, which occurred in the controls, were absent in the treated animals. These observations indicate that the growth-promoting effect of avoparcine is related to a restriction in the host animals of responses to intestinal bacteria. No adverse pathological changes were observed in the examined tissues, indicating that avoparcine was well tolerated. © 1996 Poultry Science Association, Inc. Metabolism and Nutrition nationallicence avoparcine nationallicence broiler nationallicence bromodeoxyuridine nationallicence growth promotion nationallicence histology nationallicence KRINKE A. L. Toxicology, Ciba-Geigy AG, CH-4002 Basel, Switzerland and aut JAMROZ D. Department of Animal Nutrition, Agricultural University 50-375 Wroclaw, Poland aut Poultry Science Oxford University Press 75/6(1996-06), 705-710 0032-5791 75:6<705 1996 75 ps https://doi.org/10.3382/ps.0750705 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.3382/ps.0750705 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- KRINKE A. L. Toxicology, Ciba-Geigy AG, CH-4002 Basel, Switzerland and aut NATIONALLICENCE 700 1- JAMROZ D. Department of Animal Nutrition, Agricultural University 50-375 Wroclaw, Poland aut NATIONALLICENCE 773 0- Poultry Science Oxford University Press 75/6(1996-06), 705-710 0032-5791 75:6<705 1996 75 ps Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford