caa a22 4500 397569459 CHVBK 20180308164837.0 cr unu---uuuuu 161202e199601 xx s 000 0 eng 10.3382/ps.0750130 doi (NATIONALLICENCE)oxford-10.3382/ps.0750130 Immunolocalization of Basic Fibroblastic Growth Factor in Avian Tibial Dyschondroplastic Cartilage [Elektronische Daten] [WALEED O. TWAL, JIANXIN WU, CAROL V. GAY, ROLAND M. LEACH] Recent research in our laboratory has demonstrated that basic fibroblast growth factor (bFGF) is a permissive mitogen for epiphyseal growth plate chondrocytes. Immunocytochemistry demonstrated the presence of bFGF in the proliferative and hypertrophic zones of normal epiphyseal growth plates of 4-wk-old broiler chickens. The purpose of this investigation was to extend this research to include examination of the status of bFGF in the cartilage lesion associated with tibial dyschondroplasia (TD). Immunocytochemistry revealed that the distribution of bFGF in the growth plate proximal to the TD lesion was similar to that observed with normal growth plate. However, the intensity of immunofluorescence was greatly diminished in the TD lesion. The number of chondrocytes staining positive for bFGF was also reduced. In the peripheral edges of the lesion where cartilage was being actively resorbed, the staining intensity was greatly increased when compared to the rest of the TD lesion. Similar patterns were observed in all TD tissues examined whether the lesions were spontaneous or induced by dietary treatments or genetic selection. It is hypothesized that the decrease in bFGF, a potent angiogenic factor, may be responsible for the poor vascularization of the TD lesion. © 1996 Poultry Science Association, Inc. Physiology and Reproduction nationallicence fibroblast growth factor nationallicence tibial dyschondroplasia nationallicence epiphyseal growth plate nationallicence broiler nationallicence chondrocyte nationallicence TWAL WALEED O. Department of Poultry Science and aut WU JIANXIN Department of Poultry Science and aut GAY CAROL V. Department of Poultry Science and aut LEACH ROLAND M. Department of Poultry Science and aut Poultry Science Oxford University Press 75/1(1996-01), 130-134 0032-5791 75:1<130 1996 75 ps https://doi.org/10.3382/ps.0750130 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.3382/ps.0750130 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- TWAL WALEED O. Department of Poultry Science and aut NATIONALLICENCE 700 1- WU JIANXIN Department of Poultry Science and aut NATIONALLICENCE 700 1- GAY CAROL V. Department of Poultry Science and aut NATIONALLICENCE 700 1- LEACH ROLAND M. Department of Poultry Science and aut NATIONALLICENCE 773 0- Poultry Science Oxford University Press 75/1(1996-01), 130-134 0032-5791 75:1<130 1996 75 ps Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford