caa a22 4500 397569718 CHVBK 20180308164837.0 cr unu---uuuuu 161202e199610 xx s 000 0 eng 10.1093/oxfordjournals.jmicro.a023458 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jmicro.a023458 Immunocytochemical Localization of Desmin in Human Fetal Skeletal Muscle [Elektronische Daten] [Ya-gai Yang, Takashi Makita] The distribution of desmin filaments in the skeletal and cardiac muscles of experimental animals and cultured cells have been extensively studied. The purpose of this report is to identify the distribution of desmin filaments in vivo in human fetal skeletal muscle. Using 10 nm gold-particle-labeling immunoelectron microscopy, desmin intermediate filaments were localized in skeletal muscles of 12, 20 and 29-week-old human fetuses. A number of desmin filaments were closely associated with the nascent nonstriated myofibrils. Nascent myofibrils were distributed in the subsarcolemmal space at all three developmental stages. Desmin, accompanying the nascent myofibrils, was most abundant after 12 weeks of gestation. An irregular network of desmin filaments was conspicuous in the subsarcolemmal space after 20 weeks of gestation. Desmin filaments penetrated the myofibrils and the Z-discs after 29 weeks of gestation. The developmental change in fine structural localization of desmin between 12, 20 and 29 weeks of gestation in human fetuses indicated that desmin filaments were involved in myofibril assembly in the subsarcolemmal space, and also in myofibrillogenesis in the inner space of the myofibrils. © 1996 Oxford University Press Full-length Papers nationallicence desmin nationallicence immunocytochemical localization nationallicence skeletal muscle nationallicence human fetuses nationallicence Yang Ya-gai Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchl University, 1677-1 Yoihida, Yamaguchi, 753 Japan aut Makita Takashi Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchl University, 1677-1 Yoihida, Yamaguchi, 753 Japan aut Microscopy Oxford University Press 45/5(1996-10), 401-406 0022-0744 45:5<401 1996 45 jmicro https://doi.org/10.1093/oxfordjournals.jmicro.a023458 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jmicro.a023458 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Ya-gai Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchl University, 1677-1 Yoihida, Yamaguchi, 753 Japan aut NATIONALLICENCE 700 1- Makita Takashi Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchl University, 1677-1 Yoihida, Yamaguchi, 753 Japan aut NATIONALLICENCE 773 0- Microscopy Oxford University Press 45/5(1996-10), 401-406 0022-0744 45:5<401 1996 45 jmicro Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford