caa a22 4500 397569734 CHVBK 20180308164838.0 cr unu---uuuuu 161202e199610 xx s 000 0 eng 10.1093/oxfordjournals.jmicro.a023453 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jmicro.a023453 Morphological Changes of Capillaries Associated with Muscle-Fiber Atrophy in the Extensor Digitorum Longus Muscle of Aged Rats [Elektronische Daten] [Junzo Desaki, Sadaaki Oki, Yoshiro Matsuda] We examined the structural changes of continuous capillaries in the extensor digitorum longus muscle of 6, 12 and 24-month-old normal rats. Capillaries around each muscle fiber in the sixth month were of the continuous type. In the 12th month, muscle fibers appeared almost normal except for widened intercellular spaces and degenerative changes in the subneural sarcoplasm. In the 24th month, many muscle fibers atrophied having greatly reduced diameter and irregular cross sectional profiles. Capillaries in the widened interstices, both in the 12th and 24th months, were embedded in an abundant amount of connective tissue components, including collagen fibrils and amorphous substances, and were surrounded by basal laminae arranged in concentric lamellae. Capillaries in the abundant connective tissues were mostly of the continuous type, while 10% in the 12th month and 20% in the 24th month consisted of endothelial cells with fenestrations bridged by a single-layered diaphragm. In some of the fenestrated capillaries in the 12th month, endothelial ceils became partially disrupted and formed pores at the fenestrated portions. These findings confirm that intramuscular capillaries degenerate following the partial atrophy of muscle fibers, and suggest that the occurrence of fenestrations in the endothelial cells represent a first step in the degeneration of continuous capillaries. © 1996 Oxford University Press Full-length Papers nationallicence continuous capillary nationallicence fenestration nationallicence disrupted endothelium nationallicence extensor digitorum longus muscle nationallicence rat nationallicence Desaki Junzo Department of Anatomy, Ehime University School of Medicine Shigenobu, Ehime, 791-02 Japan aut Oki Sadaaki Department of Orthopaedic Surgery, Ehime University School of Medicine Shigenobu, Ehime, 791-02 Japan aut Matsuda Yoshiro Department of Orthopaedic Surgery, Ehime University School of Medicine Shigenobu, Ehime, 791-02 Japan aut Microscopy Oxford University Press 45/5(1996-10), 364-371 0022-0744 45:5<364 1996 45 jmicro https://doi.org/10.1093/oxfordjournals.jmicro.a023453 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jmicro.a023453 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Desaki Junzo Department of Anatomy, Ehime University School of Medicine Shigenobu, Ehime, 791-02 Japan aut NATIONALLICENCE 700 1- Oki Sadaaki Department of Orthopaedic Surgery, Ehime University School of Medicine Shigenobu, Ehime, 791-02 Japan aut NATIONALLICENCE 700 1- Matsuda Yoshiro Department of Orthopaedic Surgery, Ehime University School of Medicine Shigenobu, Ehime, 791-02 Japan aut NATIONALLICENCE 773 0- Microscopy Oxford University Press 45/5(1996-10), 364-371 0022-0744 45:5<364 1996 45 jmicro Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford