caa a22 4500 397573332 CHVBK 20180308164847.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/hmg/5.3.411 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.3.411 Localization of a Non-Specific X-linked Mental Retardation Gene, MRX23, to Xq23-q24 [Elektronische Daten] [Ronald G. Gregg, Christina Palmer, Susan Kirkpatrick, Amy Simantel] More than 100 X-linked mental retardation syndromes have been described. We report the localization of the disease gene, MRX23, in one family to Xq23-24. Affected family members present with non-specific X-linked mental retardation with verbal disability (BDOAS 10, 1-100). MRX23 is tightly linked to the markers DXS1220 (Z = 3.76 at θ = 0.1) and DXS424 (Z = 3.9 at θ = 0.06). Multipoint linkage analysis, taking five loci (DXS1072−0.07-DXS1220−0.014-MRX23−0.01-DXS 424−0.08-DXS1001) at a time, gives a maximum LOD score of 6.7 between these two markers. The next most likely location, between DXS424 and DXS1001 is 120-fold less likely. Haplotype analysis also indicates the most likely location for the disease gene is between DXS1220 and DXS424. © 1996 Oxford University Press Gregg Ronald G. Waisman Center for Mental Retardation and Human Development, University of Wisconsin, Madison, WI 53706, USA aut Palmer Christina Department of Medical Genetics and Pediatrics, University of Wisconsin, Madison, WI 53706, USA aut Kirkpatrick Susan Department of Medical Genetics and Pediatrics, University of Wisconsin, Madison, WI 53706, USA aut Simantel Amy Waisman Center for Mental Retardation and Human Development, University of Wisconsin, Madison, WI 53706, USA aut Human Molecular Genetics Oxford University Press 5/3(1996-03), 411-414 0964-6906 5:3<411 1996 5 hmg https://doi.org/10.1093/hmg/5.3.411 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.3.411 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gregg Ronald G. Waisman Center for Mental Retardation and Human Development, University of Wisconsin, Madison, WI 53706, USA aut NATIONALLICENCE 700 1- Palmer Christina Department of Medical Genetics and Pediatrics, University of Wisconsin, Madison, WI 53706, USA aut NATIONALLICENCE 700 1- Kirkpatrick Susan Department of Medical Genetics and Pediatrics, University of Wisconsin, Madison, WI 53706, USA aut NATIONALLICENCE 700 1- Simantel Amy Waisman Center for Mental Retardation and Human Development, University of Wisconsin, Madison, WI 53706, USA aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/3(1996-03), 411-414 0964-6906 5:3<411 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford