caa a22 4500 397573456 CHVBK 20180308164848.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/hmg/5.5.693 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.5.693 Confirmation of Three Susceptibility Genes to Insulin-Dependent Diabetes Mellitus: IDDM4, IDDM5 and IDDM8 [Elektronische Daten] [De-Fang Luo, Raffaella Buzzetti, Jerome I. Rotter, Noel K. Maclaren, Leslie J. Raffel, Lorenza Nisticô, Claudio Giovannini, Paolo Pozzilli, Glenys Thomson, Jin-Xiong She] Previous genome-wide mapping studies have provided suggestive linkage evidence for several novel susceptibility loci responsible for insulin-dependent diabetes mellitus (IDDM); however, the evidence was not sufficient to confirm the existence of these genes. We analyzed 265 Caucasian families with IDDM and report the first evidence that meets the standard for confirmed linkage for three susceptibility loci. The maximum LOD scores (MLS) were 3.9, 4.5 and 3.6 in our data set, and 5.0, 4.6 and 5.0 for our data combined with non-overlapping data from the literature, for IDDM4 on chromosome 11q13, IDDM5 on 6q25, and IDDM8 on 6q27, respectively. However, we could not confirm linkage for IDDM3 on 15q26 and IDDM7 on 2q31-q33, or linkage disequilibrium between D2S152 and IDDM7. © 1996 Oxford University Press Luo De-Fang Department of Pathology, Immunology and Laboratory Medicine aut Buzzetti Raffaella Endocrinologia, Istituto Clinica Medica II, University of Rome ‘La Sapienza', Rome, Italy aut Rotter Jerome I. Department of Medicine and Pediatrics, Cedars-Sinai Medical Research Institute and UCLA, Los Angeles, California, USA aut Maclaren Noel K. Department of Pathology, Immunology and Laboratory Medicine aut Raffel Leslie J. Department of Medicine and Pediatrics, Cedars-Sinai Medical Research Institute and UCLA, Los Angeles, California, USA aut Nisticô Lorenza Endocrinologia, Istituto Clinica Medica II, University of Rome ‘La Sapienza', Rome, Italy aut Giovannini Claudio Endocrinologia, Istituto Clinica Medica II, University of Rome ‘La Sapienza', Rome, Italy aut Pozzilli Paolo Endocrinologia, Istituto Clinica Medica II, University of Rome ‘La Sapienza', Rome, Italy aut Thomson Glenys Department of Integrative Biology, University of California, Berkeley, California, USA aut She Jin-Xiong Department of Pathology, Immunology and Laboratory Medicine aut Human Molecular Genetics Oxford University Press 5/5(1996-05), 693-698 0964-6906 5:5<693 1996 5 hmg https://doi.org/10.1093/hmg/5.5.693 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.5.693 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luo De-Fang Department of Pathology, Immunology and Laboratory Medicine aut NATIONALLICENCE 700 1- Buzzetti Raffaella Endocrinologia, Istituto Clinica Medica II, University of Rome ‘La Sapienza', Rome, Italy aut NATIONALLICENCE 700 1- Rotter Jerome I. Department of Medicine and Pediatrics, Cedars-Sinai Medical Research Institute and UCLA, Los Angeles, California, USA aut NATIONALLICENCE 700 1- Maclaren Noel K. Department of Pathology, Immunology and Laboratory Medicine aut NATIONALLICENCE 700 1- Raffel Leslie J. Department of Medicine and Pediatrics, Cedars-Sinai Medical Research Institute and UCLA, Los Angeles, California, USA aut NATIONALLICENCE 700 1- Nisticô Lorenza Endocrinologia, Istituto Clinica Medica II, University of Rome ‘La Sapienza', Rome, Italy aut NATIONALLICENCE 700 1- Giovannini Claudio Endocrinologia, Istituto Clinica Medica II, University of Rome ‘La Sapienza', Rome, Italy aut NATIONALLICENCE 700 1- Pozzilli Paolo Endocrinologia, Istituto Clinica Medica II, University of Rome ‘La Sapienza', Rome, Italy aut NATIONALLICENCE 700 1- Thomson Glenys Department of Integrative Biology, University of California, Berkeley, California, USA aut NATIONALLICENCE 700 1- She Jin-Xiong Department of Pathology, Immunology and Laboratory Medicine aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/5(1996-05), 693-698 0964-6906 5:5<693 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford