caa a22 4500 397573502 CHVBK 20180308164848.0 cr unu---uuuuu 161202e199608 xx s 000 0 eng 10.1093/hmg/5.8.1131 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.8.1131 A Fine-Scale Comparison of the Human and Chimpanzee Genomes: Linkage, Linkage Disequilibrium and Sequence Analysis [Elektronische Daten] [B. Crouau-Roy, S. Service, M. Slatkin, N. Freimer] We have performed a fine-scale comparative study of the human and chimpanzee genomes, using linkage, linkage disequilibrium and sequence analyses on microsatellite loci spanning a region of approximately 30 cM on human chromosome 4p. Our results extend the findings of previous studies that indicated virtually complete conservation between the human and chimpanzee genomes at the chromosomal and sub-chromosomal level and port the hypothesis, derived from previous analyses of mitochondrial DNA, that chimpanzee populations are more diverse than human ones. By sequencing several human and chimpanzee alleles of two microsatellites we showed that base substitutions that diminish the length of perfect repeats (but do not change allele sizes) are probably responsible for the low heterozygosity of these loci in chimpanzees; our results suggest that the evolutionary history of microsatellites should not be inferred from comparisons of mean allele lengths between populations or species. © 1996 Oxford University Press Crouau-Roy B. Neurogenetics Laboratory, University of California San Francisco, San Francisco, CA 94143, USA aut Service S. Neurogenetics Laboratory, University of California San Francisco, San Francisco, CA 94143, USA aut Slatkin M. Department of Integrative Biology, University of California Berkeley, Berkeley, CA 94720, USA aut Freimer N. Neurogenetics Laboratory, University of California San Francisco, San Francisco, CA 94143, USA aut Human Molecular Genetics Oxford University Press 5/8(1996-08), 1131-1137 0964-6906 5:8<1131 1996 5 hmg https://doi.org/10.1093/hmg/5.8.1131 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.8.1131 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Crouau-Roy B. Neurogenetics Laboratory, University of California San Francisco, San Francisco, CA 94143, USA aut NATIONALLICENCE 700 1- Service S. Neurogenetics Laboratory, University of California San Francisco, San Francisco, CA 94143, USA aut NATIONALLICENCE 700 1- Slatkin M. Department of Integrative Biology, University of California Berkeley, Berkeley, CA 94720, USA aut NATIONALLICENCE 700 1- Freimer N. Neurogenetics Laboratory, University of California San Francisco, San Francisco, CA 94143, USA aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/8(1996-08), 1131-1137 0964-6906 5:8<1131 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford