caa a22 4500 397573537 CHVBK 20180308164848.0 cr unu---uuuuu 161202e199611 xx s 000 0 eng 10.1093/hmg/5.11.1759 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.11.1759 Network Analysis of Human Y Microsatellite Haplotypes [Elektronische Daten] [Gillian Cooper, William Amos, Dorota Hoffman, David C. Rubinsztein] To investigate the utility of Y chromosome micro-satellites for studying human male-lineage evolution, we typed samples from three populations for five tetranucleotide repeats and an Alu insertion polymorphism. We found very high levels of haplotype diversity and evidence that most mutations involve the gain or loss of only one repeat unit, implying that any given microsatellite haplotype may have arisen independently on two or more Y-chromosome lineages. Together, these factors suggest that interpretation of small sample sizes (<30) will be problematic. By typing a large sample of individuals (n = 174) from one population, East Anglia, we were able to construct a haplotype network. The network exhibits a well-connected core structure of commoner haplotypes. Computer simulations based on this network estimate the convergence time for African and Caucasian groups may be between 1.4 and 1.8 times as long as the convergence of the East Anglian population. Based on our comparison between large and small sample sizes, we suggest that large sample sizes are necessary in order to interpret Y-microsatellite haplotypes, and that a network analysis of the type we describe may prove informative in future studies. © 1996 Oxford University Press Cooper Gillian University of Cambridge, Department of Genetics, Downing Street, Cambridge CB2 3EH, UK aut Amos William University of Cambridge, Department of Genetics, Downing Street, Cambridge CB2 3EH, UK aut Hoffman Dorota East Anglian Regional Genetics Service Molecular Genetics Laboratory Department of Clinical Genetics, Box 158, Addenbrooke's NHS Trust, Hills Road, Cambridge CB2 2QQ, UK aut Rubinsztein David C. East Anglian Regional Genetics Service Molecular Genetics Laboratory Department of Clinical Genetics, Box 158, Addenbrooke's NHS Trust, Hills Road, Cambridge CB2 2QQ, UK aut Human Molecular Genetics Oxford University Press 5/11(1996-11), 1759-1766 0964-6906 5:11<1759 1996 5 hmg https://doi.org/10.1093/hmg/5.11.1759 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.11.1759 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cooper Gillian University of Cambridge, Department of Genetics, Downing Street, Cambridge CB2 3EH, UK aut NATIONALLICENCE 700 1- Amos William University of Cambridge, Department of Genetics, Downing Street, Cambridge CB2 3EH, UK aut NATIONALLICENCE 700 1- Hoffman Dorota East Anglian Regional Genetics Service Molecular Genetics Laboratory Department of Clinical Genetics, Box 158, Addenbrooke's NHS Trust, Hills Road, Cambridge CB2 2QQ, UK aut NATIONALLICENCE 700 1- Rubinsztein David C. East Anglian Regional Genetics Service Molecular Genetics Laboratory Department of Clinical Genetics, Box 158, Addenbrooke's NHS Trust, Hills Road, Cambridge CB2 2QQ, UK aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/11(1996-11), 1759-1766 0964-6906 5:11<1759 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford