caa a22 4500 397573642 CHVBK 20180308164848.0 cr unu---uuuuu 161202e199610 xx s 000 0 eng 10.1093/hmg/5.10.1637 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.10.1637 Characterization of the Human Jumonji Gene [Elektronische Daten] [Jean-Louis Bergé-Lefranc, Philippe Jay, Annick Massacrier, Pierre Cau, Marie Geneviève Mattei, Sophie Bauer, Catherine Marsollier, Philippe Berta, Michel Fontes] While constructing a cDNA library of human embryos, we have isolated a clone homologous to jumonji, a mouse gene required for neural tube formation. We have determined the complete coding sequence of the human homologue (JMJ) and deduced the amino acid sequence of the putative protein. We show here that human and mouse jumonji putative proteins are homologous and present 90% identity. During human embryogenesis, JMJ mRNAs are predominantly expressed in neurons and particularly in dorsal root ganglion cells. They are also expressed in neurons of human adult cerebral cortex. In view of these observations, we propose JMJ as a candidate gene for developmental defects of the central nervous system in the human. The human JMJ gene maps at position 6p24-6p23. © 1996 Oxford University Press Bergé-Lefranc Jean-Louis INSERM U406, Faculté de médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France, BP 5051, 34033 Montpellier cedex, France aut Jay Philippe Biochimie CNRS-INSERM, BP 5051, 34033 Montpellier cedex, France aut Massacrier Annick Laboratoire de Biologie Cellulaire (DGRT 868), Faculté de médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France aut Cau Pierre Laboratoire de Biologie Cellulaire (DGRT 868), Faculté de médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France aut Mattei Marie Geneviève INSERM U406, Faculté de médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France aut Bauer Sophie INSERM U406, Faculté de médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France aut Marsollier Catherine Biochimie CNRS-INSERM, BP 5051, 34033 Montpellier cedex, France aut Berta Philippe Biochimie CNRS-INSERM, BP 5051, 34033 Montpellier cedex, France aut Fontes Michel INSERM U406, Faculté de médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France aut Human Molecular Genetics Oxford University Press 5/10(1996-10), 1637-1641 0964-6906 5:10<1637 1996 5 hmg https://doi.org/10.1093/hmg/5.10.1637 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.10.1637 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bergé-Lefranc Jean-Louis INSERM U406, Faculté de médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France, BP 5051, 34033 Montpellier cedex, France aut NATIONALLICENCE 700 1- Jay Philippe Biochimie CNRS-INSERM, BP 5051, 34033 Montpellier cedex, France aut NATIONALLICENCE 700 1- Massacrier Annick Laboratoire de Biologie Cellulaire (DGRT 868), Faculté de médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France aut NATIONALLICENCE 700 1- Cau Pierre Laboratoire de Biologie Cellulaire (DGRT 868), Faculté de médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France aut NATIONALLICENCE 700 1- Mattei Marie Geneviève INSERM U406, Faculté de médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France aut NATIONALLICENCE 700 1- Bauer Sophie INSERM U406, Faculté de médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France aut NATIONALLICENCE 700 1- Marsollier Catherine Biochimie CNRS-INSERM, BP 5051, 34033 Montpellier cedex, France aut NATIONALLICENCE 700 1- Berta Philippe Biochimie CNRS-INSERM, BP 5051, 34033 Montpellier cedex, France aut NATIONALLICENCE 700 1- Fontes Michel INSERM U406, Faculté de médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/10(1996-10), 1637-1641 0964-6906 5:10<1637 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford