caa a22 4500 397573855 CHVBK 20180308164849.0 cr unu---uuuuu 161202e199608 xx s 000 0 eng 10.1093/hmg/5.8.1129 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.8.1129 Association between Atopic Asthma and a Coding Variant of FcεRIβ in a Japanese Population [Elektronische Daten] [T. Shirakawa, X.-Q. Mao, S. Sasaki, T. Enomoto, M. Kawai, K. Morimoto, J. Hopkin] A genetic association study was performed with coding variants of FcεRIβ in relation to atopic and non-atopic asthma in a Japanese population (n=400). A coding variant of Gly237Glu in exon 7 of FcεRIβ gene showed association with atopic asthma (OR = 3.00, χ2 = 5.10, p <0.03), but not with non-atopic asthma; this was seen particularly in childhood asthma (OR = 3.92, χ2 = 8.66, p <0.005). This variant is also associated with very high total serum IgE levels (>mean + 3 SD, OR = 8.56, χ2 = 46.2, p <0.0001), but not any allergen specific IgE. However, Leu181Ile, another variant of FcεRIβ related to atopy in British and Australian populations, was not found in this Japanese population. These results suggest that variants of FcεRIβ may be an important genetic cause of the atopic asthma. © 1996 Oxford University Press Shirakawa T. Osler Chest Unit, Churchill Hospital, Oxford, UK aut Mao X.-Q Department of Hygiene and Preventive Medicine, Osaka University School of Medicine, Suita, Japan aut Sasaki S. Department of Pediatrics, Osaka College of Medicine, Takatsuki, Japan aut Enomoto T. Department of ORL, Japanese Red Cross Society Wakayama Medical Centre, Wakayama, Japan aut Kawai M. Kyoto Preventive Medical Centre, Kyoto, Japan aut Morimoto K. Department of Hygiene and Preventive Medicine, Osaka University School of Medicine, Suita, Japan aut Hopkin J. Osler Chest Unit, Churchill Hospital, Oxford, UK aut Human Molecular Genetics Oxford University Press 5/8(1996-08), 1129-1130 0964-6906 5:8<1129 1996 5 hmg https://doi.org/10.1093/hmg/5.8.1129 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.8.1129 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shirakawa T. Osler Chest Unit, Churchill Hospital, Oxford, UK aut NATIONALLICENCE 700 1- Mao X.-Q Department of Hygiene and Preventive Medicine, Osaka University School of Medicine, Suita, Japan aut NATIONALLICENCE 700 1- Sasaki S. Department of Pediatrics, Osaka College of Medicine, Takatsuki, Japan aut NATIONALLICENCE 700 1- Enomoto T. Department of ORL, Japanese Red Cross Society Wakayama Medical Centre, Wakayama, Japan aut NATIONALLICENCE 700 1- Kawai M. Kyoto Preventive Medical Centre, Kyoto, Japan aut NATIONALLICENCE 700 1- Morimoto K. Department of Hygiene and Preventive Medicine, Osaka University School of Medicine, Suita, Japan aut NATIONALLICENCE 700 1- Hopkin J. Osler Chest Unit, Churchill Hospital, Oxford, UK aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/8(1996-08), 1129-1130 0964-6906 5:8<1129 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford