caa a22 4500 397573901 CHVBK 20180308164849.0 cr unu---uuuuu 161202e199612 xx s 000 0 eng 10.1093/hmg/5.12.2013 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.12.2013 The Human Autosomal Gene DAZLA: Testis Specificity and a Candidate for Male Infertility [Elektronische Daten] [Pauline H. Yen, Ning Ning Chai, Eduardo C. Salido] The DAZ (Deleted in AZoospermia) and DAZLA (DAZ-like autosomal) genes may be determinants of male infertility. The DAZgene on the long arm of the human Y chromosome is a strong candidate for the ‘azoospermia factor' (AZF). Its role in spermatogenesis is supported by its exclusive expression in testis, its deletion in a high percentage of males with azoospermia or severe oligospermia, and its homology with a Drosophila male infertility gene boule. No DAZ homologous sequences have been found on the mouse Y chromosome. Instead, a Dazlagene was isolated from mouse chromosome 17 and has been considered to be a murine homologue of DAZ. However, the homology between human DAZ and mouse Dazla is not strong, and Dazla contains only one of the seven DAZ repeats found in DAZ. We report the isolation of the human DAZLA gene by screening a human testis cDNA library with a DAZ cDNA clone. DAZLA encodes only one DAZ repeat and shares high homology with the mouse Dazla, indicating that these two genes are homologues. Using a panel of rodent-human somatic cell lines and fluorescence in situ hybridization, the DAZLA gene was mapped to 3p24, a region not known to share homology with mouse chromosome 17. The DAZLA gene may be involved in some familial cases of autosomal recessive male infertility. © 1993 Oxford University Press Yen Pauline H. Division of Medical Genetics, Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502-2064, USA, Spain aut Chai Ning Ning Division of Medical Genetics, Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502-2064, USA aut Salido Eduardo C. Department of Pathology, Universidad de La Laguna, Spain aut Human Molecular Genetics Oxford University Press 5/12(1996-12), 2013-2017 0964-6906 5:12<2013 1996 5 hmg https://doi.org/10.1093/hmg/5.12.2013 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.12.2013 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yen Pauline H. Division of Medical Genetics, Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502-2064, USA, Spain aut NATIONALLICENCE 700 1- Chai Ning Ning Division of Medical Genetics, Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502-2064, USA aut NATIONALLICENCE 700 1- Salido Eduardo C. Department of Pathology, Universidad de La Laguna, Spain aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/12(1996-12), 2013-2017 0964-6906 5:12<2013 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford