caa a22 4500 397574150 CHVBK 20180308164850.0 cr unu---uuuuu 161202e199606 xx s 000 0 eng 10.1093/hmg/5.6.779 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.6.779 Genetic Association between Monoamine Oxidase A Microsatellite and RFLP Alleles and Bipolar Affective Disorder: Analysis and Meta-Analysis [Elektronische Daten] [D. C. Rubinsztein, J. Leggo, S. Goodburn, C. Walsh, S. Jain, E. S. Paykel] The monoamine oxidase A locus (MAOA) at Xp11 was considered a good candidate to investigate in bipolar affective disorder since this enzyme plays an important role in the degradation of various neurotransmitters and a mutation in this gene has been associated with borderline mental retardation and a behavioural phenotype that has some resemblance to the manic syndrome. Previous association studies comparing allele frequencies of a microsatellite and RFLP at the monoamine oxidase A locus in bipolar affective disorder cases and controls in the UK have yielded conflicting results: Lim and colleagues reported a positive association, while no evidence for allelic association was obtained by Cradock and co- workers. A significant allelic association was observed between Japanese bipolar cases and controls at the MAOA microsatellite but different alleles seemed to be overrepresented in the bipolar cases in this population compared to the UK. In order to resolve these differences, we have examined this locus in our series of unrelated bipolar cases and age- and sex- matched controls and found significantly different MAOA microsatellite allele frequencies. In addition, we have pooled the data from the two previous UK studies with ours to create a total data set including 67 males and 113 females with bipolar affective disorder and a similar number of matched controls. No evidence for heterogeneity was observed for the control MAOA microsatellite or RFLP allele frequencies in these three studies. However, we found a significant difference between the pooled normal and bipolar allele frequencies both for the microsatellite and the RFLP at MAOA. © 1996 Oxford University Press Rubinsztein D. C. East Anglian Medical Genetics Service Molecular Genetics Laboratory, Box 158, Addenbrooke's NHS Trust, Hills Road, Cambridge, CB2 2QQ, UK aut Leggo J. East Anglian Medical Genetics Service Molecular Genetics Laboratory, Box 158, Addenbrooke's NHS Trust, Hills Road, Cambridge, CB2 2QQ, UK aut Goodburn S. Department of Medical Genetics, Cambridge University, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK aut Walsh C. Department of Psychiatry, Cambridge University, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK aut Jain S. Department of Psychiatry, Cambridge University, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK aut Paykel E. S. Department of Psychiatry, Cambridge University, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK aut Human Molecular Genetics Oxford University Press 5/6(1996-06), 779-782 0964-6906 5:6<779 1996 5 hmg https://doi.org/10.1093/hmg/5.6.779 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.6.779 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rubinsztein D. C. East Anglian Medical Genetics Service Molecular Genetics Laboratory, Box 158, Addenbrooke's NHS Trust, Hills Road, Cambridge, CB2 2QQ, UK aut NATIONALLICENCE 700 1- Leggo J. East Anglian Medical Genetics Service Molecular Genetics Laboratory, Box 158, Addenbrooke's NHS Trust, Hills Road, Cambridge, CB2 2QQ, UK aut NATIONALLICENCE 700 1- Goodburn S. Department of Medical Genetics, Cambridge University, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK aut NATIONALLICENCE 700 1- Walsh C. Department of Psychiatry, Cambridge University, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK aut NATIONALLICENCE 700 1- Jain S. Department of Psychiatry, Cambridge University, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK aut NATIONALLICENCE 700 1- Paykel E. S. Department of Psychiatry, Cambridge University, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/6(1996-06), 779-782 0964-6906 5:6<779 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford