caa a22 4500 397574398 CHVBK 20180308164851.0 cr unu---uuuuu 161202e199607 xx s 000 0 eng 10.1093/hmg/5.7.1029 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.7.1029 Analysis of Molecular Variance (Amova) of Y-Chromosome-Specific Microsatellites in Two Closely Related Human Populations [Elektronische Daten] [Lutz Roewer, Manfred Kayser, Patrick Dieltjes, Marion Nagy, Egbert Bakker, Michael Krawczak, Peter de Knijff] The analysis of seven Y-chromosome-specific microsatellite loci revealed a high level of polymorphism in two closely related human populations (Dutch, n = 89, and German, n = 70). Four of these loci were found to generate at least 77 different haplotypes, only 15 of which were shared by the two populations. These results demonstrate that highly informative PCR-based DNA typing of the Y chromosome is now feasible. Assuming a stepwise mutation model, a network comprising all minimum spanning evolutionary trees connecting the haplotypes was constructed. Analysis of molecular variance based upon this network indicated that the within-population heterogeneity with respect to haplotype descent was significantly smaller than the between-population heterogeneity, suggesting that males were more closely related to males from their own population as opposed to males from the other population. These findings suggest that Y-chromosomal microsatellites might be very useful not only for forensic purposes but also in association studies of multifactorial traits, allowing the characterization of the level of genetic distinctiveness of supposedly inbred or isolated populations and discrimination even between closely related populations. © 1996 Oxford University Press Roewer Lutz Institut für Gerichtliche Medizin, Humboldt-UniversitÄt, Charité, Hannoversche Strasse 6, D-10115 Berlin, Germany aut Kayser Manfred Institut für Gerichtliche Medizin, Humboldt-UniversitÄt, Charité, Hannoversche Strasse 6, D-10115 Berlin, Germany aut Dieltjes Patrick MGC-Department of Human Genetics, Leiden University, P.O. Box 9503, 2300 RA Leiden, The Netherlands aut Nagy Marion Institut für Gerichtliche Medizin, Humboldt-UniversitÄt, Charité, Hannoversche Strasse 6, D-10115 Berlin, Germany aut Bakker Egbert MGC-Department of Human Genetics, Leiden University, P.O. Box 9503, 2300 RA Leiden, The Netherlands aut Krawczak Michael Institut für Humangenetik, Medizinische Hochschule, D-30623 Hannover, Germany aut de Knijff Peter MGC-Department of Human Genetics, Leiden University, P.O. Box 9503, 2300 RA Leiden, The Netherlands aut Human Molecular Genetics Oxford University Press 5/7(1996-07), 1029-1033 0964-6906 5:7<1029 1996 5 hmg https://doi.org/10.1093/hmg/5.7.1029 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.7.1029 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Roewer Lutz Institut für Gerichtliche Medizin, Humboldt-UniversitÄt, Charité, Hannoversche Strasse 6, D-10115 Berlin, Germany aut NATIONALLICENCE 700 1- Kayser Manfred Institut für Gerichtliche Medizin, Humboldt-UniversitÄt, Charité, Hannoversche Strasse 6, D-10115 Berlin, Germany aut NATIONALLICENCE 700 1- Dieltjes Patrick MGC-Department of Human Genetics, Leiden University, P.O. Box 9503, 2300 RA Leiden, The Netherlands aut NATIONALLICENCE 700 1- Nagy Marion Institut für Gerichtliche Medizin, Humboldt-UniversitÄt, Charité, Hannoversche Strasse 6, D-10115 Berlin, Germany aut NATIONALLICENCE 700 1- Bakker Egbert MGC-Department of Human Genetics, Leiden University, P.O. Box 9503, 2300 RA Leiden, The Netherlands aut NATIONALLICENCE 700 1- Krawczak Michael Institut für Humangenetik, Medizinische Hochschule, D-30623 Hannover, Germany aut NATIONALLICENCE 700 1- de Knijff Peter MGC-Department of Human Genetics, Leiden University, P.O. Box 9503, 2300 RA Leiden, The Netherlands aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/7(1996-07), 1029-1033 0964-6906 5:7<1029 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence SWISSBIB 397574398 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford