caa a22 4500 397574568 CHVBK 20180308164851.0 cr unu---uuuuu 161202e199610 xx s 000 0 eng 10.1093/hmg/5.10.1679 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.10.1679 Susceptibility Locus for Inflammatory Bowel Disease on Chromosome 16 has a Role in Crohn's disease, but Not in Ulcerative Colitis [Elektronische Daten] [Jeffrey D. Ohmen, Hui-Ying Yang, Karen K. Yamamoto, Hong-Yu Zhao, Yuanhong Ma, L. Gordon Bentley, Zhihan Huang, Scott Gerwehr, Sheila Pressman, Colleen McElree, Stephan Targan, Jerome I. Rotter, Nathan Fischel-Ghodsian] In the Western world, chronic inflammatory bowel disease (IBD) presents as two major clinical forms, Crohn's disease (CD) and ulcerative colitis (UC) [Targan,S.R. and Shanahan,F. (1994) In Retford,D.C (ed.), Inflammatory Bowel Disease: From Bench to Bedside. Williams and Wilkins, Baltimore]. Genetic epidemiological studies, the occurrence of rare syndromes associated with IBD, and animal models suggest that inherited factors play significant roles in the susceptibility to both forms of IBD [Yang,H.-Y. and Rotter,J.I. (1995) In Kirsner,J.B. and Shorter,R.G. (eds), Genetic Aspects of Idiopathic inflammatory Bowel Disease. Williams and Wilkins, Baltimore, pp. 301-331]. Recently, a genome-wide search on European families with multiple affected members with CD identified a putative susceptibility locus in the centromeric region of chromosome 16 [Hugot,J.-P. et al. (1996) Nature, 379, 821-823]. We have now tested this region in an independent set of US families, confirmed that this region is likely to contain a gene predisposing to CD, and further refined the chromosomal location of this gene. Most importantly with respect to this locus, our data also seem to indicate that there is heterogeneity both within the CD group, and between the CD and UC groups with respect to this locus. The susceptibility locus appears to be involved only in non-Jewish CD sibpairs and not in our Ashkenazi Jewish CD sibpairs. Additionally, we have tested sibpairs having either only UC or both UC and CD for involvement of this locus, and have found no evidence that this region predisposes to IBD in these patients. © 1996 Oxford University Press Ohmen Jeffrey D. GenoMed Pharmaceuticals, Inc., Suite 360, 150 N. Robertson Blvd, Beverly Hills, CA 90211, USA aut Yang Hui-Ying Departments of Medical Genetics and Pediatrics, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA aut Yamamoto Karen K. GenoMed Pharmaceuticals, Inc., Suite 360, 150 N. Robertson Blvd, Beverly Hills, CA 90211, USA aut Zhao Hong-Yu Department of Biostatistics, UCLA School of Public Health, 10833 LeConte Avenue, Los Angeles, CA 90095, USA aut Ma Yuanhong GenoMed Pharmaceuticals, Inc., Suite 360, 150 N. Robertson Blvd, Beverly Hills, CA 90211, USA aut Bentley L. Gordon GenoMed Pharmaceuticals, Inc., Suite 360, 150 N. Robertson Blvd, Beverly Hills, CA 90211, USA aut Huang Zhihan Departments of Medical Genetics and Pediatrics, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA aut Gerwehr Scott GenoMed Pharmaceuticals, Inc., Suite 360, 150 N. Robertson Blvd, Beverly Hills, CA 90211, USA aut Pressman Sheila Departments of Medical Genetics and Pediatrics, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA aut McElree Colleen Departments of Medical Genetics and Pediatrics, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA aut Targan Stephan Department of Medicine, Division of Gastroenterology, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA aut Rotter Jerome I. Departments of Medical Genetics and Pediatrics, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA aut Fischel-Ghodsian Nathan GenoMed Pharmaceuticals, Inc., Suite 360, 150 N. Robertson Blvd, Beverly Hills, CA 90211, USA aut Human Molecular Genetics Oxford University Press 5/10(1996-10), 1679-1683 0964-6906 5:10<1679 1996 5 hmg https://doi.org/10.1093/hmg/5.10.1679 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.10.1679 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohmen Jeffrey D. GenoMed Pharmaceuticals, Inc., Suite 360, 150 N. Robertson Blvd, Beverly Hills, CA 90211, USA aut NATIONALLICENCE 700 1- Yang Hui-Ying Departments of Medical Genetics and Pediatrics, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA aut NATIONALLICENCE 700 1- Yamamoto Karen K. GenoMed Pharmaceuticals, Inc., Suite 360, 150 N. Robertson Blvd, Beverly Hills, CA 90211, USA aut NATIONALLICENCE 700 1- Zhao Hong-Yu Department of Biostatistics, UCLA School of Public Health, 10833 LeConte Avenue, Los Angeles, CA 90095, USA aut NATIONALLICENCE 700 1- Ma Yuanhong GenoMed Pharmaceuticals, Inc., Suite 360, 150 N. Robertson Blvd, Beverly Hills, CA 90211, USA aut NATIONALLICENCE 700 1- Bentley L. Gordon GenoMed Pharmaceuticals, Inc., Suite 360, 150 N. Robertson Blvd, Beverly Hills, CA 90211, USA aut NATIONALLICENCE 700 1- Huang Zhihan Departments of Medical Genetics and Pediatrics, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA aut NATIONALLICENCE 700 1- Gerwehr Scott GenoMed Pharmaceuticals, Inc., Suite 360, 150 N. Robertson Blvd, Beverly Hills, CA 90211, USA aut NATIONALLICENCE 700 1- Pressman Sheila Departments of Medical Genetics and Pediatrics, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA aut NATIONALLICENCE 700 1- McElree Colleen Departments of Medical Genetics and Pediatrics, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA aut NATIONALLICENCE 700 1- Targan Stephan Department of Medicine, Division of Gastroenterology, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA aut NATIONALLICENCE 700 1- Rotter Jerome I. Departments of Medical Genetics and Pediatrics, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA aut NATIONALLICENCE 700 1- Fischel-Ghodsian Nathan GenoMed Pharmaceuticals, Inc., Suite 360, 150 N. Robertson Blvd, Beverly Hills, CA 90211, USA aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/10(1996-10), 1679-1683 0964-6906 5:10<1679 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford