caa a22 4500 397574703 CHVBK 20180308164852.0 cr unu---uuuuu 161202e199601 xx s 000 0 eng 10.1093/hmg/5.1.41 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.1.41 Cloning and Characterization of a Murine Brain Specific Gene Bpx and Its Human Homologue Lying within the Xic Candidate Region [Elektronische Daten] [Claire Rougeulle, Philip Avner] The X inactivation centre (Xic) is a cis-acting locus thought to play a key role in the initiation of X-inactivation. We have cloned and characterized a new gene, Bpx, lying distal to the murine Xist. Bpx, which is specifically expressed in the brain, shows strong homology to genes encoding nucleosome assembly proteins and is normally X-inactivated in mice. Isolation and localization of BPX, its human homologue, has shown the gene to be located centromeric to XIST in man. The Xq13 region, whose orientation is apparently globally conserved between man and mouse, must therefore contain an inversion of at least 600 kb spanning the XIST sequence and including the CDX4 and BPX genes. © 1996 Oxford University Press Rougeulle Claire Unité de Génétique Moléculaire Murine, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France aut Avner Philip Unité de Génétique Moléculaire Murine, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France aut Human Molecular Genetics Oxford University Press 5/1(1996-01), 41-49 0964-6906 5:1<41 1996 5 hmg https://doi.org/10.1093/hmg/5.1.41 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.1.41 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rougeulle Claire Unité de Génétique Moléculaire Murine, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France aut NATIONALLICENCE 700 1- Avner Philip Unité de Génétique Moléculaire Murine, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/1(1996-01), 41-49 0964-6906 5:1<41 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford